Setting description

Equal randomization: Carboplatin more effective in the DRD+ biomarker signature (cfr scen 6)

Simulations setting

PFS distributions


Treatment effects

By subgroup:

subtype var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-+-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
+— param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
+++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31


By signature:

signature var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
all param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.075, shape = 1.05 scale = 0.075, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 13.1, median = 9.4 mean = 13.1, median = 9.4
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.49, hr = 0.66 af = 1.49, hr = 0.66
TP53- & AR- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.075, shape = 1.05 scale = 0.075, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 13.1, median = 9.4 mean = 13.1, median = 9.4
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.49, hr = 0.66 af = 1.49, hr = 0.66
TP53+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.075, shape = 1.05 scale = 0.075, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 13.1, median = 9.4 mean = 13.1, median = 9.4
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.49, hr = 0.66 af = 1.49, hr = 0.66
DRD+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.075, shape = 1.05 scale = 0.075, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 13.1, median = 9.4 mean = 13.1, median = 9.4
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.49, hr = 0.66 af = 1.49, hr = 0.66

Errors and power


graduation (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 4 2 13 19
TP53- & AR- 9 11 134 151
TP53+ 6 5 25 27
DRD+ 0 0 322 321
TEfus+ 4 2 24 24
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.008 0.004 0.026 0.038
TP53- & AR- 0.018 0.022 0.268 0.302
TP53+ 0.012 0.010 0.050 0.054
DRD+ 0.000 0.000 0.644 0.642
TEfus+ 0.008 0.004 0.048 0.048
futility (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 6 4 1 0
TP53- & AR- 203 216 9 6
TP53+ 75 49 2 1
DRD+ 173 160 0 0
TEfus+ 64 45 1 2
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.012 0.008 0.002 0.000
TP53- & AR- 0.406 0.432 0.018 0.012
TP53+ 0.150 0.098 0.004 0.002
DRD+ 0.346 0.320 0.000 0.000
TEfus+ 0.128 0.090 0.002 0.004
max sample size (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0 0 0 0
TP53- & AR- 7 6 6 15
TP53+ 7 17 4 9
DRD+ 0 0 0 0
TEfus+ 1 0 0 0
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.000 0.000 0.000 0.000
TP53- & AR- 0.014 0.012 0.012 0.030
TP53+ 0.014 0.034 0.008 0.018
DRD+ 0.000 0.000 0.000 0.000
TEfus+ 0.002 0.000 0.000 0.000


Errors & power

The overall error was 0.276.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.044             0.036             0.126             0.110 

The overall power was 0.872.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.000             0.000             0.644             0.642 

Median results at the end of the trial

By signature:
signature var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
all graduation 0 4 2 13 19
futility 0 6 4 1 0
max_n 0 0 0 0 0
n 278 (246, 321) 217 (145, 280) 225 (157, 286) 227 (164, 275) 224 (155, 282)
n_unique 254 (226, 292) 200 (134, 260) 208 (143, 266) 209 (152, 255) 204 (143, 260)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 6 (4, 21) 4 (4, 26) 12 (5, 28) 22 (5, 34)
post_p NA (NA, NA) 0.42 (0.08, 0.85) 0.46 (0.1, 0.9) 1 (0.94, 1) 1 (0.94, 1)
rate 0.113 (0.102, 0.122) 0.113 (0.103, 0.126) 0.112 (0.101, 0.124) 0.083 (0.073, 0.093) 0.082 (0.072, 0.093)
TP53- & AR- graduation 0 9 11 134 151
futility 0 203 216 9 6
max_n 0 7 6 6 15
n 119 (97, 144) 88 (28, 123) 90 (28, 126) 95 (31, 126) 92 (29, 129)
n_unique 109 (89, 133) 83 (27, 115) 85 (26, 119) 88 (29, 117) 86 (26, 120)
time_trial 36 (36, 36) 36 (12, 36) 36 (12, 36) 36 (14, 36) 36 (12, 36)
time_stop NA (NA, NA) 16 (10, 30) 17 (10, 31) 17 (9, 29) 15 (9, 29)
post_p NA (NA, NA) 0.41 (0.09, 0.84) 0.41 (0.08, 0.84) 0.95 (0.62, 1) 0.96 (0.61, 1)
rate 0.113 (0.099, 0.128) 0.114 (0.097, 0.14) 0.114 (0.097, 0.143) 0.085 (0.07, 0.104) 0.084 (0.067, 0.102)
TP53+ graduation 0 6 5 25 27
futility 0 75 49 2 1
max_n 0 7 17 4 9
n 120 (102, 144) 104 (47, 127) 108 (70, 133) 103 (77, 124) 103 (78, 129)
n_unique 109 (93, 130) 95 (43, 117) 100 (63, 124) 95 (70, 115) 95 (71, 118)
time_trial 36 (36, 36) 36 (21, 36) 36 (34, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 17 (9, 30) 18 (9, 31) 17 (10, 26) 16 (9, 29)
post_p NA (NA, NA) 0.4 (0.1, 0.81) 0.46 (0.11, 0.86) 0.96 (0.74, 1) 0.96 (0.7, 1)
rate 0.113 (0.099, 0.128) 0.114 (0.1, 0.135) 0.113 (0.098, 0.13) 0.084 (0.071, 0.098) 0.084 (0.07, 0.099)
DRD+ graduation 0 0 0 322 321
futility 0 173 160 0 0
max_n 0 0 0 0 0
n 85 (67, 107) 62 (29, 91) 66 (31, 98) 53 (26, 85) 53 (26, 87)
n_unique 78 (61, 100) 56 (26, 84) 60 (28, 90) 47 (23, 76) 47 (24, 80)
time_trial 36 (36, 36) 36 (19, 36) 36 (19, 36) 30 (15, 36) 29 (15, 36)
time_stop NA (NA, NA) 23 (13, 33) 23 (15, 34) 22 (14, 33) 21 (13, 34)
post_p NA (NA, NA) 0.27 (0.05, 0.73) 0.3 (0.03, 0.7) 1 (1, 1) 1 (1, 1)
rate 0.113 (0.097, 0.131) 0.115 (0.093, 0.141) 0.113 (0.094, 0.141) 0.036 (0.028, 0.046) 0.036 (0.026, 0.045)
TEfus+ graduation 0 4 2 24 24
futility 0 64 45 1 2
max_n 0 1 0 0 0
n 105 (88, 126) 81 (39, 108) 87 (53, 112) 81 (57, 107) 82 (56, 108)
n_unique 96 (80, 116) 75 (36, 98) 80 (49, 103) 74 (52, 98) 75 (49, 98)
time_trial 36 (36, 36) 36 (25, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 15 (11, 32) 20 (12, 30) 15 (10, 27) 14 (10, 24)
post_p NA (NA, NA) 0.41 (0.06, 0.82) 0.42 (0.09, 0.86) 0.99 (0.86, 1) 0.99 (0.83, 1)
rate 0.112 (0.099, 0.13) 0.114 (0.096, 0.139) 0.112 (0.095, 0.133) 0.074 (0.061, 0.089) 0.074 (0.06, 0.089)


By subgroup combinations:
subtype var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- graduation 0 218 231 152 165
futility 0 0 0 0 0
max_n 0 7 6 6 15
n 71 (55, 92) 56 (17, 75) 54 (18, 78) 62 (21, 83) 60 (19, 82)
n_unique 65 (51, 85) 53 (16, 72) 52 (17, 73) 58 (19, 78) 56 (17, 77)
post_p NA (NA, NA) 0.49 (0.11, 0.88) 0.46 (0.1, 0.87) 0.54 (0.14, 0.88) 0.55 (0.11, 0.86)
rate 0.113 (0.094, 0.134) 0.113 (0.094, 0.144) 0.115 (0.093, 0.147) 0.112 (0.093, 0.134) 0.112 (0.092, 0.135)
—+ graduation 0 241 248 165 178
futility 0 0 0 0 0
max_n 0 8 6 6 15
n 15 (10, 22) 10 (3, 17) 10 (3, 19) 12 (3, 19) 12 (3, 19)
n_unique 14 (8, 20) 9 (3, 16) 9 (3, 17) 11 (3, 18) 10 (3, 17)
post_p NA (NA, NA) 0.5 (0.18, 0.82) 0.47 (0.18, 0.84) 0.52 (0.18, 0.84) 0.52 (0.19, 0.82)
rate 0.115 (0.078, 0.172) 0.117 (0.078, 0.212) 0.117 (0.079, 0.22) 0.11 (0.072, 0.17) 0.112 (0.07, 0.17)
–+- graduation 0 88 58 40 44
futility 0 0 0 0 0
max_n 0 7 17 4 9
n 37 (29, 47) 34 (15, 44) 35 (23, 44) 35 (26, 45) 36 (25, 45)
n_unique 34 (26, 44) 32 (15, 41) 32 (21, 42) 33 (24, 42) 33 (23, 42)
post_p NA (NA, NA) 0.5 (0.13, 0.85) 0.52 (0.16, 0.88) 0.53 (0.16, 0.88) 0.49 (0.14, 0.87)
rate 0.114 (0.089, 0.143) 0.115 (0.09, 0.153) 0.113 (0.089, 0.146) 0.113 (0.088, 0.143) 0.115 (0.087, 0.145)
–++ graduation 0 139 92 59 63
futility 0 0 0 0 0
max_n 0 7 17 4 9
n 25 (19, 35) 22 (8, 31) 23 (12, 32) 24 (15, 32) 24 (14, 32)
n_unique 23 (16, 32) 21 (7, 28) 21 (11, 29) 22 (14, 30) 22 (13, 30)
post_p NA (NA, NA) 0.47 (0.15, 0.84) 0.51 (0.16, 0.86) 0.5 (0.15, 0.86) 0.53 (0.14, 0.84)
rate 0.113 (0.084, 0.152) 0.118 (0.084, 0.167) 0.112 (0.086, 0.156) 0.113 (0.083, 0.152) 0.112 (0.083, 0.151)
-+– graduation 0 302 299 378 373
futility 0 0 0 0 0
max_n 0 7 6 6 12
n 16 (9, 23) 10 (3, 20) 10 (3, 19) 9 (3, 17) 9 (3, 17)
n_unique 14 (9, 21) 9 (3, 18) 9 (3, 18) 8 (3, 16) 8 (3, 16)
post_p NA (NA, NA) 0.3 (0.09, 0.66) 0.31 (0.08, 0.62) 0.94 (0.75, 0.99) 0.94 (0.71, 1)
rate 0.114 (0.079, 0.168) 0.119 (0.077, 0.206) 0.119 (0.078, 0.227) 0.036 (0.017, 0.063) 0.036 (0.015, 0.067)
-+-+ graduation 0 316 309 383 376
futility 0 0 0 0 0
max_n 0 8 6 6 12
n 16 (10, 23) 9 (3, 20) 10 (3, 20) 9 (3, 17) 8 (3, 18)
n_unique 15 (9, 22) 8 (2, 18) 9 (3, 18) 8 (2, 16) 8 (3, 16)
post_p NA (NA, NA) 0.31 (0.08, 0.63) 0.3 (0.1, 0.65) 0.93 (0.71, 0.99) 0.94 (0.72, 1)
rate 0.111 (0.078, 0.166) 0.121 (0.076, 0.222) 0.117 (0.076, 0.211) 0.037 (0.016, 0.066) 0.036 (0.016, 0.062)
-++- graduation 0 232 193 340 328
futility 0 0 0 0 0
max_n 0 6 17 2 9
n 9 (5, 13) 7 (2, 12) 7 (3, 13) 5 (2, 10) 6 (2, 11)
n_unique 8 (4, 12) 6 (2, 11) 6 (2, 12) 5 (1, 9) 5 (2, 11)
post_p NA (NA, NA) 0.32 (0.11, 0.63) 0.32 (0.11, 0.64) 0.84 (0.59, 0.97) 0.87 (0.59, 0.98)
rate 0.118 (0.072, 0.192) 0.123 (0.072, 0.242) 0.119 (0.072, 0.217) 0.037 (0.014, 0.085) 0.034 (0.014, 0.072)
-+++ graduation 0 259 210 346 334
futility 0 0 0 0 0
max_n 0 6 17 2 9
n 9 (5, 13) 6 (1, 11) 7 (2, 13) 5 (2, 11) 6 (2, 11)
n_unique 8 (4, 12) 6 (1, 10) 6 (2, 12) 5 (2, 10) 5 (2, 10)
post_p NA (NA, NA) 0.33 (0.12, 0.63) 0.34 (0.1, 0.62) 0.86 (0.59, 0.97) 0.85 (0.59, 0.98)
rate 0.115 (0.07, 0.194) 0.121 (0.069, 0.256) 0.118 (0.065, 0.219) 0.035 (0.015, 0.073) 0.034 (0.013, 0.072)
+— graduation 0 10 6 14 19
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 12 (8, 17) 12 (8, 17) 12 (8, 17) 12 (7, 17) 12 (7, 17)
n_unique 11 (7, 16) 11 (6, 16) 11 (7, 16) 11 (6, 16) 11 (6, 16)
post_p NA (NA, NA) 0.49 (0.18, 0.82) 0.52 (0.18, 0.85) 0.48 (0.16, 0.86) 0.5 (0.15, 0.81)
rate 0.114 (0.073, 0.171) 0.115 (0.075, 0.176) 0.113 (0.074, 0.177) 0.116 (0.072, 0.182) 0.116 (0.076, 0.182)
+–+ graduation 0 76 51 38 43
futility 0 0 0 0 0
max_n 0 1 0 0 0
n 10 (6, 14) 9 (4, 14) 9 (5, 14) 9 (5, 14) 9 (5, 14)
n_unique 9 (5, 13) 8 (4, 13) 8 (4, 13) 8 (5, 13) 8 (4, 13)
post_p NA (NA, NA) 0.48 (0.19, 0.8) 0.51 (0.18, 0.85) 0.5 (0.18, 0.81) 0.5 (0.17, 0.83)
rate 0.115 (0.071, 0.186) 0.117 (0.077, 0.202) 0.112 (0.068, 0.193) 0.113 (0.071, 0.192) 0.115 (0.069, 0.185)
+-+- graduation 0 88 58 40 44
futility 0 0 0 0 0
max_n 0 7 17 4 9
n 10 (6, 14) 9 (4, 13) 9 (5, 14) 10 (5, 14) 10 (5, 14)
n_unique 9 (5, 13) 8 (4, 12) 9 (4, 13) 9 (5, 13) 9 (5, 13)
post_p NA (NA, NA) 0.48 (0.15, 0.78) 0.5 (0.18, 0.82) 0.5 (0.18, 0.82) 0.52 (0.17, 0.81)
rate 0.11 (0.069, 0.179) 0.118 (0.073, 0.215) 0.115 (0.071, 0.19) 0.112 (0.068, 0.201) 0.116 (0.07, 0.184)
+-++ graduation 0 139 92 59 63
futility 0 0 0 0 0
max_n 0 7 17 4 9
n 10 (6, 16) 9 (3, 14) 9 (4, 15) 9 (4, 15) 10 (4, 14)
n_unique 10 (6, 15) 8 (2, 13) 9 (3, 14) 8 (4, 13) 8 (4, 13)
post_p NA (NA, NA) 0.48 (0.17, 0.82) 0.53 (0.16, 0.83) 0.5 (0.19, 0.82) 0.51 (0.18, 0.82)
rate 0.114 (0.075, 0.183) 0.121 (0.073, 0.212) 0.112 (0.069, 0.204) 0.115 (0.066, 0.197) 0.113 (0.066, 0.192)
++– graduation 0 182 164 331 327
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 9 (5, 13) 7 (2, 12) 7 (3, 12) 5 (2, 11) 6 (2, 11)
n_unique 8 (4, 12) 6 (2, 11) 7 (2, 11) 5 (2, 10) 5 (2, 9)
post_p NA (NA, NA) 0.34 (0.1, 0.62) 0.34 (0.11, 0.62) 0.84 (0.55, 0.97) 0.85 (0.55, 0.97)
rate 0.117 (0.07, 0.191) 0.118 (0.07, 0.232) 0.118 (0.067, 0.223) 0.039 (0.012, 0.079) 0.039 (0.011, 0.078)
++-+ graduation 0 216 186 339 334
futility 0 0 0 0 0
max_n 0 1 0 0 0
n 9 (5, 13) 7 (2, 12) 7 (3, 12) 5 (2, 11) 5 (2, 11)
n_unique 8 (4, 12) 6 (2, 11) 7 (3, 12) 5 (2, 10) 5 (2, 9)
post_p NA (NA, NA) 0.34 (0.12, 0.63) 0.34 (0.12, 0.65) 0.85 (0.56, 0.98) 0.85 (0.58, 0.97)
rate 0.116 (0.071, 0.206) 0.121 (0.067, 0.232) 0.116 (0.064, 0.199) 0.037 (0.013, 0.077) 0.037 (0.014, 0.082)
+++- graduation 0 232 193 340 328
futility 0 0 0 0 0
max_n 0 6 17 2 9
n 9 (5, 14) 6 (2, 11) 7 (2, 11) 5 (2, 10) 5 (2, 11)
n_unique 8 (4, 13) 6 (2, 10) 6 (2, 11) 4 (2, 9) 5 (1, 10)
post_p NA (NA, NA) 0.35 (0.13, 0.65) 0.33 (0.11, 0.66) 0.83 (0.56, 0.97) 0.86 (0.55, 0.97)
rate 0.119 (0.068, 0.197) 0.12 (0.064, 0.228) 0.116 (0.067, 0.215) 0.036 (0.014, 0.079) 0.036 (0.012, 0.077)
++++ graduation 0 259 210 346 334
futility 0 0 0 0 0
max_n 0 6 17 2 9
n 9 (5, 14) 6 (2, 13) 7 (2, 12) 5 (2, 10) 5 (2, 11)
n_unique 8 (5, 13) 6 (1, 11) 6 (2, 11) 5 (1, 9) 5 (1, 10)
post_p NA (NA, NA) 0.34 (0.12, 0.64) 0.32 (0.11, 0.62) 0.85 (0.52, 0.98) 0.85 (0.59, 0.97)
rate 0.114 (0.067, 0.209) 0.122 (0.068, 0.242) 0.121 (0.07, 0.248) 0.038 (0.012, 0.085) 0.038 (0.013, 0.077)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 4 2 13 19
time_stop 4 (4, 5) 4 (4, 4) 15 (6, 28) 22 (5, 34)
n_trt 26 (25, 28) 29 (28, 30) 87 (36, 178) 107 (31, 182)
n_control 26 (18, 31) 25 (23, 27) 102 (40, 214) 156 (30, 254)
post_p 0.89 (0.85, 0.92) 0.91 (0.88, 0.93) 0.99 (0.96, 1) 1 (0.97, 1)
order 1 (1, 1) 1 (1, 1) 1 (1, 3.8) 3 (1, 4)
TP53- & AR- count 9 11 134 151
time_stop 12 (10, 14) 12 (10, 19) 18 (9, 29) 15 (9, 30)
n_trt 33 (27, 38) 27 (25, 43) 48 (26, 92) 40 (26, 86)
n_control 32 (25, 43) 36 (26, 57) 51 (22, 90) 44 (24, 91)
post_p 0.93 (0.88, 0.97) 0.93 (0.86, 0.97) 0.96 (0.9, 1) 0.97 (0.9, 1)
order 1 (1, 2) 2 (1, 3) 2 (1, 3) 1 (1, 3)
TP53+ count 6 5 25 27
time_stop 8 (7, 9) 10 (9, 11) 18 (9, 27) 16 (10, 29)
n_trt 26 (25, 29) 30 (27, 33) 46 (25, 78) 48 (27, 86)
n_control 20 (20, 26) 35 (28, 38) 57 (23, 93) 52 (27, 96)
post_p 0.93 (0.9, 0.97) 0.96 (0.94, 0.97) 0.99 (0.94, 1) 0.98 (0.96, 1)
order 1 (1, 1) 2 (1, 2) 2 (1, 4) 2 (1, 3)
DRD+ count 322 321
time_stop 22 (14, 33) 21 (13, 34)
n_trt 39 (25, 74) 37 (26, 69)
n_control 45 (24, 79) 43 (25, 74)
post_p 1 (0.99, 1) 1 (0.99, 1)
order 2 (1, 3) 2 (1, 3)
TEfus+ count 4 2 24 24
time_stop 13 (9, 16) 12 (12, 13) 14 (10, 28) 15 (10, 24)
n_trt 30 (26, 40) 26 (25, 28) 32 (27, 53) 30 (25, 51)
n_control 28 (23, 50) 34 (32, 36) 40 (23, 75) 40 (27, 72)
post_p 0.94 (0.87, 0.97) 0.95 (0.91, 0.99) 0.98 (0.92, 1) 1 (0.96, 1)
order 1.5 (1, 2.7) 2.5 (1.3, 3.7) 2 (1, 3) 2 (1, 3)
Futility:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 6 4 1
time_stop 13 (6, 25) 14 (4, 28) 4 (4, 4)
n_trt 65 (40, 142) 77 (29, 153) 30 (30, 30)
n_control 94 (37, 196) 110 (29, 236) 29 (29, 29)
post_p 0.05 (0.02, 0.17) 0.03 (0.01, 0.09) 0.09 (0.09, 0.09)
order 2 (1, 3.5) 3.5 (1, 6) 1 (1, 1)
TP53- & AR- count 203 216 9 6
time_stop 17 (10, 30) 17 (10, 31) 10 (9, 14) 11 (10, 18)
n_trt 43 (26, 86) 44 (26, 92) 26 (25, 32) 27 (26, 42)
n_control 46 (23, 95) 46 (24, 100) 28 (24, 37) 32 (24, 46)
post_p 0.16 (0.05, 0.26) 0.16 (0.04, 0.28) 0.16 (0.03, 0.23) 0.18 (0.09, 0.25)
order 1 (1, 3) 1 (1, 3) 1 (1, 1.2) 1 (1, 3)
TP53+ count 75 49 2 1
time_stop 18 (9, 30) 19 (9, 32) 11 (11, 11) 8 (8, 8)
n_trt 47 (28, 96) 59 (27, 100) 28 (26, 31) 28 (28, 28)
n_control 49 (26, 102) 58 (25, 104) 34 (32, 37) 13 (13, 13)
post_p 0.09 (0.02, 0.19) 0.09 (0.02, 0.19) 0.1 (0.07, 0.13) 0.21 (0.21, 0.21)
order 2 (1, 3) 2 (1, 3) 1 (1, 1) 1 (1, 1)
DRD+ count 173 160
time_stop 23 (13, 33) 23 (15, 34)
n_trt 41 (26, 68) 42 (26, 71)
n_control 47 (24, 79) 46 (27, 78)
post_p 0.08 (0.01, 0.22) 0.08 (0.01, 0.22)
order 2 (1, 4) 2 (1, 4)
TEfus+ count 64 45 1 2
time_stop 15 (11, 33) 20 (12, 30) 18 (18, 18) 9 (8, 10)
n_trt 36 (25, 75) 47 (30, 75) 47 (47, 47) 26 (25, 27)
n_control 37 (23, 96) 52 (28, 91) 45 (45, 45) 22 (18, 26)
post_p 0.06 (0, 0.17) 0.07 (0.02, 0.19) 0.08 (0.08, 0.08) 0.05 (0.04, 0.06)
order 2 (1, 4) 2 (1, 4) 1 (1, 1) 1 (1, 1)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
time 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5)
n 7 (6, 9) 0 (0, 2) 4 (2, 5) 2 (1, 4) 0 (0, 1) 1 (1, 2) 0 (0, 1) 0 (0, 2) 0 (0, 2) 2 (0, 2) 1 (1, 2) 2 (0, 3) 0 (0, 2) 1 (0, 2) 2 (1, 2) 0 (0, 2)
post_p 0.67 (0.56, 0.76) 0.88 (0.88, 0.88) 0.69 (0.63, 0.79) 0.58 (0.56, 0.62) 0.59 (0.57, 0.61) 0.61 (0.55, 0.66) 0.52 (0.52, 0.52) 0.78 (0.78, 0.78) 0.66 (0.61, 0.71) 0.7 (0.67, 0.74) 0.56 (0.56, 0.56) 0.57 (0.57, 0.57) NA (NA, NA) 0.56 (0.56, 0.56) 0.56 (0.53, 0.59) 0.67 (0.67, 0.67)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.054 (0.015, 0.1) 0.09 (0.09, 0.09) 0 (0, 0.05) 0 (0, 0) 0 (0, 0) 0 (0, 0.303) 0.191 (0.191, 0.191) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1.006) 0 (0, 0.245) 0.227 (0.045, 0.408) 0 (0, 0) 0 (0, 0) 0 (0, 0)
Taxel_therapies count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
time 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4)
n 10 (5, 15) 2 (0, 4) 5 (4, 6) 3 (3, 3) 2 (1, 2) 0 (0, 0) 0 (0, 0) 2 (0, 4) 2 (1, 2) 2 (1, 2) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 1 (0, 2) 1 (0, 2)
post_p 0.64 (0.56, 0.73) 0.66 (0.66, 0.66) 0.67 (0.6, 0.74) 0.52 (0.52, 0.53) 0.65 (0.58, 0.72) NA (NA, NA) NA (NA, NA) 0.64 (0.64, 0.64) 0.56 (0.54, 0.57) 0.6 (0.55, 0.66) 0.57 (0.57, 0.57) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.58 (0.58, 0.58)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.013 (0.003, 0.024) 0.116 (0.116, 0.116) 0 (0, 0) 0.055 (0.011, 0.1) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0)
Carboplatin count 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13
time 15 (6, 28) 15 (6, 28) 15 (6, 28) 15 (6, 28) 15 (6, 28) 15 (6, 28) 15 (6, 28) 15 (6, 28) 15 (6, 28) 15 (6, 28) 15 (6, 28) 15 (6, 28) 15 (6, 28) 15 (6, 28) 15 (6, 28) 15 (6, 28)
n 14 (8, 40) 5 (1, 10) 13 (6, 29) 6 (2, 24) 3 (1, 8) 3 (1, 9) 3 (0, 7) 3 (0, 7) 5 (1, 12) 3 (1, 8) 4 (0, 7) 3 (0, 8) 2 (0, 6) 2 (0, 6) 3 (0, 6) 3 (1, 6)
post_p 0.68 (0.52, 0.9) 0.64 (0.53, 0.77) 0.63 (0.53, 0.77) 0.57 (0.52, 0.71) 0.61 (0.51, 0.86) 0.66 (0.52, 0.86) 0.65 (0.53, 0.85) 0.69 (0.53, 0.86) 0.67 (0.55, 0.96) 0.56 (0.51, 0.79) 0.7 (0.56, 0.89) 0.58 (0.55, 0.74) 0.62 (0.58, 0.89) 0.72 (0.56, 0.88) 0.59 (0.52, 0.84) 0.75 (0.56, 0.88)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.085 (0.063, 0.096) 0.071 (0, 0.106) 0.1 (0.05, 0.13) 0.087 (0.008, 0.131) 0.034 (0, 0.097) 0.023 (0, 0.052) 0.015 (0, 0.063) 0.021 (0, 0.072) 0.034 (0, 0.109) 0.087 (0, 0.134) 0.048 (0, 0.071) 0.084 (0, 0.129) 0.011 (0, 0.064) 0 (0, 0.036) 0 (0, 0.078) 0 (0, 0.043)
Niraparib count 19 19 19 19 19 19 19 19 19 19 19 19 19 19 19 19
time 22 (5, 34) 22 (5, 34) 22 (5, 34) 22 (5, 34) 22 (5, 34) 22 (5, 34) 22 (5, 34) 22 (5, 34) 22 (5, 34) 22 (5, 34) 22 (5, 34) 22 (5, 34) 22 (5, 34) 22 (5, 34) 22 (5, 34) 22 (5, 34)
n 21 (6, 51) 4 (1, 15) 18 (4, 31) 9 (3, 21) 5 (2, 8) 3 (1, 10) 3 (1, 7) 2 (0, 7) 6 (1, 12) 6 (1, 10) 5 (1, 12) 4 (1, 11) 3 (1, 6) 4 (2, 7) 3 (0, 6) 3 (1, 8)
post_p 0.68 (0.61, 0.82) 0.63 (0.51, 0.77) 0.66 (0.53, 0.87) 0.62 (0.53, 0.82) 0.73 (0.64, 0.94) 0.82 (0.59, 0.94) 0.73 (0.57, 0.9) 0.75 (0.65, 0.93) 0.6 (0.51, 0.74) 0.59 (0.51, 0.8) 0.7 (0.54, 0.83) 0.63 (0.52, 0.9) 0.64 (0.51, 0.93) 0.76 (0.59, 0.9) 0.58 (0.52, 0.94) 0.72 (0.59, 0.86)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.1 (0.053, 0.112) 0.071 (0, 0.105) 0.088 (0.033, 0.11) 0.091 (0.043, 0.118) 0.029 (0, 0.068) 0.036 (0, 0.081) 0.039 (0, 0.079) 0.017 (0, 0.037) 0.089 (0, 0.112) 0.091 (0.023, 0.122) 0.066 (0, 0.13) 0.043 (0, 0.114) 0.023 (0, 0.078) 0.017 (0, 0.051) 0.036 (0, 0.103) 0.018 (0, 0.051)
TP53- & AR- Hormone_therapies count 9 9 9 9
time 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14)
n 18 (16, 25) 4 (3, 5) 4 (2, 5) 4 (2, 10)
post_p 0.82 (0.8, 0.9) 0.6 (0.51, 0.77) 0.67 (0.53, 0.71) 0.63 (0.54, 0.84)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.079 (0.051, 0.098) 0.058 (0, 0.108) 0.042 (0, 0.114) 0.029 (0, 0.062)
Taxel_therapies count 11 11 11 11
time 12 (10, 19) 12 (10, 19) 12 (10, 19) 12 (10, 19)
n 19 (14, 30) 3 (2, 6) 3 (2, 5) 4 (3, 5)
post_p 0.8 (0.74, 0.9) 0.69 (0.51, 0.84) 0.64 (0.53, 0.76) 0.68 (0.56, 0.77)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.087 (0.067, 0.098) 0.048 (0, 0.173) 0 (0, 0.076) 0.053 (0, 0.119)
Carboplatin count 134 134 134 134
time 18 (9, 29) 18 (9, 29) 18 (9, 29) 18 (9, 29)
n 31 (17, 56) 5 (2, 12) 5 (2, 13) 5 (2, 13)
post_p 0.77 (0.71, 0.92) 0.71 (0.53, 0.87) 0.78 (0.58, 0.94) 0.78 (0.58, 0.96)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.088 (0.061, 0.115) 0.07 (0, 0.118) 0.031 (0, 0.057) 0.031 (0, 0.061)
Niraparib count 151 151 151 151
time 15 (9, 30) 15 (9, 30) 15 (9, 30) 15 (9, 30)
n 27 (16, 55) 4 (1, 12) 5 (2, 12) 5 (2, 10)
post_p 0.76 (0.71, 0.9) 0.7 (0.53, 0.84) 0.8 (0.58, 0.95) 0.78 (0.6, 0.95)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.088 (0.054, 0.11) 0.073 (0, 0.104) 0.025 (0, 0.056) 0.025 (0, 0.059)
TP53+ Hormone_therapies count 6 6 6 6 6 6 6 6
time 8 (7, 9) 8 (7, 9) 8 (7, 9) 8 (7, 9) 8 (7, 9) 8 (7, 9) 8 (7, 9) 8 (7, 9)
n 12 (9, 12) 6 (3, 8) 2 (0, 3) 1 (0, 2) 4 (3, 5) 2 (0, 2) 2 (1, 3) 0 (0, 2)
post_p 0.82 (0.77, 0.88) 0.72 (0.64, 0.86) 0.53 (0.51, 0.55) 0.65 (0.62, 0.68) 0.7 (0.67, 0.83) 0.54 (0.54, 0.6) 0.52 (0.51, 0.59) NA (NA, NA)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.042 (0.029, 0.071) 0.022 (0, 0.091) 0 (0, 0) 0 (0, 0) 0.061 (0, 0.155) 0.064 (0, 0.144) 0.08 (0, 0.225) 0 (0, 0.506)
Taxel_therapies count 5 5 5 5 5 5 5 5
time 10 (9, 11) 10 (9, 11) 10 (9, 11) 10 (9, 11) 10 (9, 11) 10 (9, 11) 10 (9, 11) 10 (9, 11)
n 10 (9, 15) 7 (6, 9) 1 (0, 3) 2 (1, 4) 3 (1, 4) 1 (0, 3) 1 (1, 3) 3 (0, 4)
post_p 0.79 (0.74, 0.85) 0.72 (0.68, 0.76) 0.53 (0.52, 0.86) 0.55 (0.52, 0.71) 0.77 (0.67, 0.82) 0.84 (0.62, 0.88) 0.58 (0.53, 0.61) 0.55 (0.53, 0.7)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.047 (0.034, 0.053) 0.055 (0.05, 0.085) 0.028 (0.006, 0.127) 0.061 (0, 0.131) 0 (0, 0.042) 0 (0, 0) 0 (0, 0.05) 0.068 (0.051, 0.115)
Carboplatin count 25 25 25 25 25 25 25 25
time 18 (9, 27) 18 (9, 27) 18 (9, 27) 18 (9, 27) 18 (9, 27) 18 (9, 27) 18 (9, 27) 18 (9, 27)
n 14 (7, 29) 10 (4, 18) 3 (1, 7) 3 (0, 8) 4 (0, 7) 4 (1, 8) 3 (0, 6) 2 (1, 5)
post_p 0.76 (0.73, 0.88) 0.75 (0.6, 0.85) 0.73 (0.56, 0.92) 0.76 (0.59, 0.93) 0.64 (0.51, 0.77) 0.74 (0.54, 0.86) 0.68 (0.52, 0.91) 0.66 (0.54, 0.9)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.077 (0.033, 0.111) 0.074 (0.014, 0.099) 0.018 (0, 0.072) 0.025 (0, 0.046) 0.077 (0, 0.145) 0.06 (0, 0.107) 0.009 (0, 0.061) 0 (0, 0.091)
Niraparib count 27 27 27 27 27 27 27 27
time 16 (10, 29) 16 (10, 29) 16 (10, 29) 16 (10, 29) 16 (10, 29) 16 (10, 29) 16 (10, 29) 16 (10, 29)
n 19 (8, 32) 11 (5, 21) 3 (1, 7) 3 (1, 6) 5 (1, 9) 4 (2, 7) 3 (1, 4) 2 (1, 5)
post_p 0.78 (0.71, 0.88) 0.78 (0.71, 0.87) 0.77 (0.62, 0.94) 0.69 (0.54, 0.84) 0.71 (0.56, 0.87) 0.69 (0.53, 0.83) 0.63 (0.52, 0.81) 0.67 (0.52, 0.91)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.073 (0.032, 0.104) 0.079 (0.036, 0.097) 0.016 (0, 0.048) 0 (0, 0.048) 0.059 (0, 0.105) 0.07 (0, 0.116) 0.016 (0, 0.085) 0 (0, 0.057)
DRD+ Carboplatin count 322 322 322 322 322 322 322 322
time 22 (14, 33) 22 (14, 33) 22 (14, 33) 22 (14, 33) 22 (14, 33) 22 (14, 33) 22 (14, 33) 22 (14, 33)
n 7 (3, 15) 7 (3, 15) 4 (1, 9) 4 (2, 10) 4 (1, 9) 4 (2, 9) 4 (2, 9) 4 (2, 9)
post_p 0.82 (0.65, 0.98) 0.83 (0.63, 0.97) 0.74 (0.54, 0.93) 0.75 (0.55, 0.92) 0.75 (0.54, 0.93) 0.76 (0.55, 0.92) 0.74 (0.56, 0.92) 0.75 (0.54, 0.93)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.032 (0, 0.059) 0.031 (0, 0.061) 0.03 (0, 0.08) 0.032 (0, 0.069) 0.029 (0, 0.066) 0.028 (0, 0.073) 0.031 (0, 0.067) 0.03 (0, 0.084)
Niraparib count 321 321 321 321 321 321 321 321
time 21 (13, 34) 21 (13, 34) 21 (13, 34) 21 (13, 34) 21 (13, 34) 21 (13, 34) 21 (13, 34) 21 (13, 34)
n 7 (3, 15) 6 (3, 14) 4 (1, 9) 4 (1, 9) 4 (2, 8) 4 (2, 8) 4 (1, 9) 4 (1, 9)
post_p 0.82 (0.61, 0.99) 0.85 (0.64, 0.97) 0.75 (0.57, 0.93) 0.76 (0.54, 0.93) 0.74 (0.54, 0.94) 0.74 (0.53, 0.92) 0.74 (0.54, 0.93) 0.75 (0.54, 0.93)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.03 (0, 0.062) 0.031 (0, 0.063) 0.029 (0, 0.069) 0.027 (0, 0.06) 0.028 (0, 0.073) 0.027 (0, 0.068) 0.026 (0, 0.076) 0.029 (0, 0.066)
TEfus+ Hormone_therapies count 4 4 4 4 4 4 4 4
time 13 (9, 16) 13 (9, 16) 13 (9, 16) 13 (9, 16) 13 (9, 16) 13 (9, 16) 13 (9, 16) 13 (9, 16)
n 5 (3, 7) 7 (4, 15) 4 (3, 5) 2 (1, 3) 3 (2, 4) 2 (1, 4) 2 (0, 5) 4 (3, 4)
post_p 0.81 (0.7, 0.86) 0.68 (0.62, 0.81) 0.58 (0.54, 0.65) 0.52 (0.51, 0.56) 0.68 (0.54, 0.87) 0.62 (0.57, 0.67) 0.64 (0.54, 0.73) 0.66 (0.55, 0.74)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.019 (0, 0.059) 0.048 (0.014, 0.083) 0.038 (0.008, 0.085) 0.075 (0.021, 0.101) 0.088 (0.061, 0.137) 0 (0, 0.069) 0.028 (0.006, 0.041) 0.045 (0.011, 0.073)
Taxel_therapies count 2 2 2 2 2 2 2 2
time 12 (12, 13) 12 (12, 13) 12 (12, 13) 12 (12, 13) 12 (12, 13) 12 (12, 13) 12 (12, 13) 12 (12, 13)
n 6 (5, 6) 10 (9, 12) 2 (1, 4) 1 (1, 1) 4 (3, 4) 2 (0, 3) 2 (1, 2) 0 (0, 1)
post_p 0.63 (0.53, 0.73) 0.87 (0.86, 0.87) 0.83 (0.83, 0.83) 0.66 (0.65, 0.68) 0.7 (0.7, 0.71) 0.62 (0.62, 0.62) 0.62 (0.61, 0.63) 0.55 (0.55, 0.55)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.06 (0.032, 0.087) 0.061 (0.058, 0.064) 0.119 (0.119, 0.119) 0 (0, 0) 0.103 (0.061, 0.145) 0.052 (0.052, 0.052) 0.04 (0.008, 0.073) 0 (0, 0)
Carboplatin count 24 24 24 24 24 24 24 24
time 14 (10, 28) 14 (10, 28) 14 (10, 28) 14 (10, 28) 14 (10, 28) 14 (10, 28) 14 (10, 28) 14 (10, 28)
n 4 (2, 11) 11 (6, 17) 3 (1, 7) 2 (0, 5) 4 (3, 7) 2 (1, 6) 3 (1, 4) 3 (1, 7)
post_p 0.64 (0.52, 0.79) 0.79 (0.72, 0.94) 0.7 (0.55, 0.91) 0.61 (0.53, 0.77) 0.65 (0.54, 0.78) 0.63 (0.52, 0.8) 0.66 (0.53, 0.85) 0.71 (0.58, 0.82)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.072 (0.007, 0.134) 0.068 (0.034, 0.097) 0.006 (0, 0.054) 0 (0, 0.056) 0.07 (0.012, 0.127) 0.048 (0, 0.125) 0.018 (0, 0.077) 0 (0, 0.091)
Niraparib count 24 24 24 24 24 24 24 24
time 15 (10, 24) 15 (10, 24) 15 (10, 24) 15 (10, 24) 15 (10, 24) 15 (10, 24) 15 (10, 24) 15 (10, 24)
n 4 (1, 6) 8 (4, 17) 5 (1, 9) 3 (1, 5) 3 (2, 7) 4 (2, 7) 3 (2, 6) 2 (1, 5)
post_p 0.67 (0.54, 0.83) 0.76 (0.7, 0.89) 0.82 (0.63, 0.92) 0.68 (0.53, 0.86) 0.7 (0.56, 0.81) 0.7 (0.54, 0.78) 0.72 (0.53, 0.84) 0.65 (0.54, 0.83)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.055 (0, 0.089) 0.064 (0.035, 0.091) 0 (0, 0.039) 0 (0, 0.075) 0.077 (0, 0.11) 0.07 (0, 0.124) 0.017 (0, 0.069) 0.034 (0, 0.072)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6
time 13 (6, 25) 13 (6, 25) 13 (6, 25) 13 (6, 25) 13 (6, 25) 13 (6, 25) 13 (6, 25) 13 (6, 25) 13 (6, 25) 13 (6, 25) 13 (6, 25) 13 (6, 25) 13 (6, 25) 13 (6, 25) 13 (6, 25) 13 (6, 25)
n 19 (12, 28) 4 (2, 6) 8 (4, 26) 5 (4, 13) 3 (2, 6) 2 (0, 8) 1 (0, 4) 2 (0, 7) 3 (2, 6) 4 (0, 6) 4 (1, 9) 2 (0, 8) 2 (0, 7) 2 (0, 5) 2 (0, 6) 3 (0, 4)
post_p 0.33 (0.05, 0.44) 0.39 (0.31, 0.45) 0.38 (0.24, 0.46) 0.41 (0.31, 0.49) 0.41 (0.27, 0.44) 0.39 (0.16, 0.41) 0.42 (0.19, 0.47) 0.39 (0.32, 0.45) 0.41 (0.29, 0.48) 0.38 (0.27, 0.42) 0.36 (0.1, 0.45) 0.4 (0.34, 0.46) 0.31 (0.23, 0.43) 0.37 (0.24, 0.44) 0.29 (0.24, 0.43) 0.3 (0.24, 0.37)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.124 (0.096, 0.181) 0.137 (0.085, 0.167) 0.149 (0.115, 0.295) 0.128 (0.071, 0.207) 0.118 (0.086, 0.131) 0.164 (0.1, 0.511) 0.129 (0.033, 0.242) 0.112 (0.067, 0.846) 0.18 (0.118, 0.389) 0.142 (0.037, 0.299) 0.168 (0.114, 0.411) 0.134 (0.107, 0.331) 0.163 (0.092, 0.888) 0.146 (0.117, 0.212) 0.204 (0.105, 0.245) 0.118 (0.11, 0.151)
Taxel_therapies count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
time 14 (4, 28) 14 (4, 28) 14 (4, 28) 14 (4, 28) 14 (4, 28) 14 (4, 28) 14 (4, 28) 14 (4, 28) 14 (4, 28) 14 (4, 28) 14 (4, 28) 14 (4, 28) 14 (4, 28) 14 (4, 28) 14 (4, 28) 14 (4, 28)
n 22 (6, 54) 6 (3, 10) 12 (5, 22) 8 (3, 14) 4 (2, 7) 2 (0, 6) 1 (0, 1) 2 (1, 4) 4 (1, 7) 2 (0, 4) 2 (0, 5) 2 (0, 3) 4 (1, 6) 2 (2, 3) 4 (1, 8) 1 (0, 5)
post_p 0.35 (0.16, 0.46) 0.36 (0.32, 0.44) 0.37 (0.26, 0.47) 0.33 (0.2, 0.46) 0.28 (0.22, 0.39) 0.35 (0.33, 0.36) 0.41 (0.3, 0.48) 0.34 (0.17, 0.42) 0.24 (0.21, 0.41) 0.27 (0.14, 0.38) 0.28 (0.25, 0.39) 0.32 (0.26, 0.36) 0.42 (0.17, 0.45) 0.25 (0.14, 0.4) 0.37 (0.22, 0.43) 0.24 (0.16, 0.32)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.14 (0.106, 0.2) 0.133 (0.097, 0.185) 0.18 (0.128, 0.262) 0.128 (0.112, 0.151) 0.143 (0.113, 0.32) 0.173 (0.123, 3.05) 0.174 (0.035, 1.541) 0.224 (0.027, 0.437) 0.306 (0.262, 0.433) 0.628 (0.361, 1.226) 0.184 (0.136, 0.58) 0.225 (0.162, 0.746) 0.263 (0.138, 0.841) 0.297 (0.02, 0.554) 0.136 (0.118, 0.202) 0.183 (0.165, 0.202)
Carboplatin count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4)
n 6 (6, 6) 1 (1, 1) 6 (6, 6) 3 (3, 3) 0 (0, 0) 1 (1, 1) 0 (0, 0) 2 (2, 2) 3 (3, 3) 0 (0, 0) 0 (0, 0) 1 (1, 1) 0 (0, 0) 4 (4, 4) 1 (1, 1) 2 (2, 2)
post_p 0.05 (0.05, 0.05) 0.48 (0.48, 0.48) 0.19 (0.19, 0.19) 0.47 (0.47, 0.47) NA (NA, NA) 0.22 (0.22, 0.22) NA (NA, NA) NA (NA, NA) 0.48 (0.48, 0.48) NA (NA, NA) NA (NA, NA) 0.5 (0.5, 0.5) NA (NA, NA) 0.45 (0.45, 0.45) NA (NA, NA) 0.43 (0.43, 0.43)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.257 (0.257, 0.257) 0 (0, 0) 0.211 (0.211, 0.211) 0.141 (0.141, 0.141) NA (NA, NA) 0.955 (0.955, 0.955) NA (NA, NA) 0 (0, 0) 0.141 (0.141, 0.141) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53- & AR- Hormone_therapies count 203 203 203 203
time 17 (10, 30) 17 (10, 30) 17 (10, 30) 17 (10, 30)
n 26 (15, 56) 6 (2, 11) 6 (3, 12) 5 (2, 11)
post_p 0.3 (0.11, 0.46) 0.39 (0.15, 0.48) 0.34 (0.09, 0.48) 0.31 (0.12, 0.47)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.128 (0.102, 0.172) 0.145 (0.096, 0.325) 0.128 (0.079, 0.266) 0.14 (0.085, 0.305)
Taxel_therapies count 216 216 216 216
time 17 (10, 31) 17 (10, 31) 17 (10, 31) 17 (10, 31)
n 28 (16, 56) 6 (2, 13) 5 (2, 12) 6 (3, 13)
post_p 0.32 (0.09, 0.47) 0.36 (0.12, 0.48) 0.33 (0.11, 0.47) 0.31 (0.1, 0.47)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.127 (0.104, 0.179) 0.152 (0.095, 0.336) 0.133 (0.079, 0.327) 0.13 (0.081, 0.338)
Carboplatin count 9 9 9 9
time 10 (9, 14) 10 (9, 14) 10 (9, 14) 10 (9, 14)
n 17 (14, 23) 4 (2, 7) 4 (3, 5) 4 (0, 6)
post_p 0.22 (0.13, 0.35) 0.35 (0.21, 0.44) 0.43 (0.26, 0.47) 0.44 (0.23, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.141 (0.12, 0.183) 0.137 (0.081, 0.524) 0.102 (0.053, 0.146) 0.11 (0.054, 0.204)
Niraparib count 6 6 6 6
time 11 (10, 18) 11 (10, 18) 11 (10, 18) 11 (10, 18)
n 20 (18, 26) 3 (1, 8) 3 (1, 5) 4 (1, 7)
post_p 0.34 (0.12, 0.48) 0.3 (0.17, 0.42) 0.41 (0.33, 0.47) 0.45 (0.34, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.118 (0.095, 0.162) 0.302 (0.097, 0.358) 0.112 (0.101, 0.801) 0.122 (0.035, 0.172)
TP53+ Hormone_therapies count 75 75 75 75 75 75 75 75
time 18 (9, 30) 18 (9, 30) 18 (9, 30) 18 (9, 30) 18 (9, 30) 18 (9, 30) 18 (9, 30) 18 (9, 30)
n 15 (9, 32) 10 (4, 24) 4 (0, 8) 3 (1, 8) 5 (1, 11) 4 (1, 8) 4 (1, 8) 3 (1, 9)
post_p 0.33 (0.11, 0.48) 0.35 (0.17, 0.49) 0.33 (0.14, 0.46) 0.33 (0.15, 0.44) 0.35 (0.16, 0.48) 0.36 (0.15, 0.49) 0.33 (0.18, 0.48) 0.35 (0.12, 0.46)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.133 (0.105, 0.198) 0.135 (0.107, 0.23) 0.131 (0.079, 0.334) 0.151 (0.069, 0.417) 0.156 (0.091, 0.35) 0.174 (0.102, 0.352) 0.125 (0.048, 0.316) 0.14 (0.088, 0.344)
Taxel_therapies count 49 49 49 49 49 49 49 49
time 19 (9, 32) 19 (9, 32) 19 (9, 32) 19 (9, 32) 19 (9, 32) 19 (9, 32) 19 (9, 32) 19 (9, 32)
n 18 (8, 29) 13 (5, 22) 4 (1, 8) 4 (1, 7) 4 (1, 10) 5 (1, 10) 5 (0, 9) 4 (1, 9)
post_p 0.29 (0.12, 0.47) 0.36 (0.15, 0.48) 0.33 (0.16, 0.45) 0.35 (0.2, 0.47) 0.34 (0.18, 0.45) 0.39 (0.14, 0.48) 0.34 (0.15, 0.48) 0.31 (0.18, 0.46)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.138 (0.11, 0.181) 0.14 (0.108, 0.25) 0.115 (0.063, 0.317) 0.125 (0.081, 0.379) 0.161 (0.11, 0.373) 0.167 (0.088, 0.383) 0.129 (0.06, 0.339) 0.151 (0.097, 0.579)
Carboplatin count 2 2 2 2 2 2 2 2
time 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11)
n 10 (8, 13) 6 (4, 9) 2 (1, 2) 2 (0, 4) 4 (2, 5) 3 (1, 5) 2 (0, 3) 0 (0, 0)
post_p 0.35 (0.23, 0.47) 0.33 (0.25, 0.41) 0.4 (0.32, 0.48) 0.46 (0.46, 0.46) 0.39 (0.34, 0.44) 0.31 (0.24, 0.38) 0.28 (0.28, 0.28) NA (NA, NA)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.131 (0.116, 0.146) 0.156 (0.136, 0.176) 14.383 (2.877, 25.889) 0.07 (0.07, 0.07) 0.132 (0.131, 0.133) 0.248 (0.14, 0.356) 0.131 (0.131, 0.131) NA (NA, NA)
Niraparib count 1 1 1 1 1 1 1 1
time 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8)
n 4 (4, 4) 9 (9, 9) 2 (2, 2) 3 (3, 3) 5 (5, 5) 3 (3, 3) 1 (1, 1) 1 (1, 1)
post_p 0.25 (0.25, 0.25) 0.28 (0.28, 0.28) NA (NA, NA) 0.48 (0.48, 0.48) 0.34 (0.34, 0.34) 0.44 (0.44, 0.44) 0.46 (0.46, 0.46) 0.41 (0.41, 0.41)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.287 (0.287, 0.287) 0.176 (0.176, 0.176) 0 (0, 0) 0 (0, 0) 0.106 (0.106, 0.106) 0.155 (0.155, 0.155) 0 (0, 0) 0.257 (0.257, 0.257)
DRD+ Hormone_therapies count 173 173 173 173 173 173 173 173
time 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33)
n 7 (3, 14) 7 (3, 13) 5 (2, 9) 4 (1, 9) 5 (2, 9) 4 (2, 8) 4 (1, 8) 5 (1, 9)
post_p 0.28 (0.11, 0.47) 0.28 (0.09, 0.45) 0.3 (0.11, 0.47) 0.31 (0.13, 0.46) 0.33 (0.13, 0.47) 0.33 (0.12, 0.45) 0.33 (0.14, 0.47) 0.35 (0.14, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.131 (0.086, 0.231) 0.139 (0.089, 0.27) 0.136 (0.079, 0.307) 0.144 (0.08, 0.346) 0.125 (0.074, 0.293) 0.133 (0.071, 0.289) 0.127 (0.07, 0.303) 0.14 (0.085, 0.308)
Taxel_therapies count 160 160 160 160 160 160 160 160
time 23 (15, 34) 23 (15, 34) 23 (15, 34) 23 (15, 34) 23 (15, 34) 23 (15, 34) 23 (15, 34) 23 (15, 34)
n 6 (2, 14) 6 (3, 13) 5 (2, 9) 4 (2, 9) 5 (2, 9) 5 (2, 10) 5 (2, 9) 5 (1, 9)
post_p 0.3 (0.11, 0.46) 0.3 (0.09, 0.46) 0.34 (0.19, 0.47) 0.3 (0.14, 0.47) 0.34 (0.13, 0.47) 0.32 (0.11, 0.47) 0.32 (0.11, 0.47) 0.3 (0.14, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.126 (0.079, 0.354) 0.132 (0.086, 0.252) 0.124 (0.081, 0.277) 0.129 (0.077, 0.289) 0.128 (0.076, 0.341) 0.137 (0.082, 0.334) 0.133 (0.076, 0.313) 0.14 (0.084, 0.366)
TEfus+ Hormone_therapies count 64 64 64 64 64 64 64 64
time 15 (11, 33) 15 (11, 33) 15 (11, 33) 15 (11, 33) 15 (11, 33) 15 (11, 33) 15 (11, 33) 15 (11, 33)
n 5 (3, 11) 10 (6, 23) 5 (2, 10) 3 (1, 8) 4 (2, 8) 4 (1, 9) 3 (1, 7) 3 (1, 7)
post_p 0.39 (0.13, 0.48) 0.31 (0.13, 0.47) 0.26 (0.09, 0.44) 0.34 (0.13, 0.46) 0.37 (0.17, 0.48) 0.3 (0.09, 0.46) 0.34 (0.19, 0.46) 0.33 (0.19, 0.46)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.145 (0.094, 0.267) 0.146 (0.099, 0.241) 0.157 (0.089, 0.296) 0.154 (0.062, 0.589) 0.165 (0.101, 0.466) 0.177 (0.103, 0.417) 0.146 (0.061, 0.38) 0.145 (0.082, 0.335)
Taxel_therapies count 45 45 45 45 45 45 45 45
time 20 (12, 30) 20 (12, 30) 20 (12, 30) 20 (12, 30) 20 (12, 30) 20 (12, 30) 20 (12, 30) 20 (12, 30)
n 7 (2, 12) 12 (6, 22) 5 (2, 14) 4 (0, 7) 5 (2, 12) 5 (2, 9) 4 (2, 8) 4 (2, 8)
post_p 0.4 (0.18, 0.48) 0.37 (0.19, 0.48) 0.31 (0.13, 0.42) 0.35 (0.24, 0.45) 0.32 (0.14, 0.47) 0.38 (0.18, 0.49) 0.32 (0.2, 0.45) 0.34 (0.14, 0.47)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.139 (0.09, 0.283) 0.131 (0.107, 0.185) 0.127 (0.077, 0.364) 0.13 (0.081, 0.367) 0.164 (0.104, 0.431) 0.182 (0.106, 0.264) 0.136 (0.083, 0.386) 0.141 (0.097, 0.313)
Carboplatin count 1 1 1 1 1 1 1 1
time 18 (18, 18) 18 (18, 18) 18 (18, 18) 18 (18, 18) 18 (18, 18) 18 (18, 18) 18 (18, 18) 18 (18, 18)
n 11 (11, 11) 14 (14, 14) 12 (12, 12) 2 (2, 2) 2 (2, 2) 2 (2, 2) 3 (3, 3) 1 (1, 1)
post_p 0.24 (0.24, 0.24) 0.19 (0.19, 0.19) 0.4 (0.4, 0.4) 0.5 (0.5, 0.5) 0.43 (0.43, 0.43) 0.16 (0.16, 0.16) 0.4 (0.4, 0.4) 0.35 (0.35, 0.35)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.14 (0.14, 0.14) 0.143 (0.143, 0.143) 0.06 (0.06, 0.06) 0.074 (0.074, 0.074) 0.147 (0.147, 0.147) 0.282 (0.282, 0.282) 0.073 (0.073, 0.073) 0.807 (0.807, 0.807)
Niraparib count 2 2 2 2 2 2 2 2
time 9 (8, 10) 9 (8, 10) 9 (8, 10) 9 (8, 10) 9 (8, 10) 9 (8, 10) 9 (8, 10) 9 (8, 10)
n 3 (3, 3) 10 (8, 12) 3 (2, 4) 0 (0, 0) 4 (2, 5) 2 (1, 3) 3 (2, 4) 1 (0, 2)
post_p 0.4 (0.34, 0.46) 0.29 (0.23, 0.34) 0.35 (0.26, 0.45) NA (NA, NA) 0.28 (0.23, 0.33) 0.41 (0.36, 0.46) 0.25 (0.1, 0.4) 0.47 (0.47, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.125 (0.084, 0.166) 0.123 (0.101, 0.146) 0.123 (0.076, 0.17) NA (NA, NA) 0.344 (0.286, 0.401) 1.454 (0.364, 2.543) 0.267 (0.224, 0.31) 0 (0, 0)