Simulation scenario 9

Setting description

Equal randomization: Carboplatin more effective in the DRD+ biomarker signature (cfr scen 6)

Simulations setting

PFS distributions

Treatment effects

By subgroup:

subtype	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
—-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
-+-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
-++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
-+++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
+—	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
++-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
+++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
++++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31

By signature:

signature	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.075, shape = 1.05	scale = 0.075, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 13.1, median = 9.4	mean = 13.1, median = 9.4
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.49, hr = 0.66	af = 1.49, hr = 0.66
TP53- & AR-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.075, shape = 1.05	scale = 0.075, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 13.1, median = 9.4	mean = 13.1, median = 9.4
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.49, hr = 0.66	af = 1.49, hr = 0.66
TP53+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.075, shape = 1.05	scale = 0.075, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 13.1, median = 9.4	mean = 13.1, median = 9.4
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.49, hr = 0.66	af = 1.49, hr = 0.66
DRD+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
TEfus+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.075, shape = 1.05	scale = 0.075, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 13.1, median = 9.4	mean = 13.1, median = 9.4
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.49, hr = 0.66	af = 1.49, hr = 0.66

Errors and power

graduation (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 4 2 13 19 TP53- & AR- 9 11 134 151 TP53+ 6 5 25 27 DRD+ 0 0 322 321 TEfus+ 4 2 24 24

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.008 0.004 0.026 0.038 TP53- & AR- 0.018 0.022 0.268 0.302 TP53+ 0.012 0.010 0.050 0.054 DRD+ 0.000 0.000 0.644 0.642 TEfus+ 0.008 0.004 0.048 0.048

futility (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 6 4 1 0 TP53- & AR- 203 216 9 6 TP53+ 75 49 2 1 DRD+ 173 160 0 0 TEfus+ 64 45 1 2

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.012 0.008 0.002 0.000 TP53- & AR- 0.406 0.432 0.018 0.012 TP53+ 0.150 0.098 0.004 0.002 DRD+ 0.346 0.320 0.000 0.000 TEfus+ 0.128 0.090 0.002 0.004

max sample size (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0 0 0 0 TP53- & AR- 7 6 6 15 TP53+ 7 17 4 9 DRD+ 0 0 0 0 TEfus+ 1 0 0 0

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.000 0.000 0.000 0.000 TP53- & AR- 0.014 0.012 0.012 0.030 TP53+ 0.014 0.034 0.008 0.018 DRD+ 0.000 0.000 0.000 0.000 TEfus+ 0.002 0.000 0.000 0.000

Errors & power

The overall error was 0.276.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.044             0.036             0.126             0.110 

The overall power was 0.872.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.000             0.000             0.644             0.642 

Median results at the end of the trial

By signature:

signature	var	Control	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	graduation	0	4	2	13	19
	futility	0	6	4	1	0
	max_n	0	0	0	0	0
	n	278 (246, 321)	217 (145, 280)	225 (157, 286)	227 (164, 275)	224 (155, 282)
	n_unique	254 (226, 292)	200 (134, 260)	208 (143, 266)	209 (152, 255)	204 (143, 260)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	6 (4, 21)	4 (4, 26)	12 (5, 28)	22 (5, 34)
	post_p	NA (NA, NA)	0.42 (0.08, 0.85)	0.46 (0.1, 0.9)	1 (0.94, 1)	1 (0.94, 1)
	rate	0.113 (0.102, 0.122)	0.113 (0.103, 0.126)	0.112 (0.101, 0.124)	0.083 (0.073, 0.093)	0.082 (0.072, 0.093)
TP53- & AR-	graduation	0	9	11	134	151
	futility	0	203	216	9	6
	max_n	0	7	6	6	15
	n	119 (97, 144)	88 (28, 123)	90 (28, 126)	95 (31, 126)	92 (29, 129)
	n_unique	109 (89, 133)	83 (27, 115)	85 (26, 119)	88 (29, 117)	86 (26, 120)
	time_trial	36 (36, 36)	36 (12, 36)	36 (12, 36)	36 (14, 36)	36 (12, 36)
	time_stop	NA (NA, NA)	16 (10, 30)	17 (10, 31)	17 (9, 29)	15 (9, 29)
	post_p	NA (NA, NA)	0.41 (0.09, 0.84)	0.41 (0.08, 0.84)	0.95 (0.62, 1)	0.96 (0.61, 1)
	rate	0.113 (0.099, 0.128)	0.114 (0.097, 0.14)	0.114 (0.097, 0.143)	0.085 (0.07, 0.104)	0.084 (0.067, 0.102)
TP53+	graduation	0	6	5	25	27
	futility	0	75	49	2	1
	max_n	0	7	17	4	9
	n	120 (102, 144)	104 (47, 127)	108 (70, 133)	103 (77, 124)	103 (78, 129)
	n_unique	109 (93, 130)	95 (43, 117)	100 (63, 124)	95 (70, 115)	95 (71, 118)
	time_trial	36 (36, 36)	36 (21, 36)	36 (34, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	17 (9, 30)	18 (9, 31)	17 (10, 26)	16 (9, 29)
	post_p	NA (NA, NA)	0.4 (0.1, 0.81)	0.46 (0.11, 0.86)	0.96 (0.74, 1)	0.96 (0.7, 1)
	rate	0.113 (0.099, 0.128)	0.114 (0.1, 0.135)	0.113 (0.098, 0.13)	0.084 (0.071, 0.098)	0.084 (0.07, 0.099)
DRD+	graduation	0	0	0	322	321
	futility	0	173	160	0	0
	max_n	0	0	0	0	0
	n	85 (67, 107)	62 (29, 91)	66 (31, 98)	53 (26, 85)	53 (26, 87)
	n_unique	78 (61, 100)	56 (26, 84)	60 (28, 90)	47 (23, 76)	47 (24, 80)
	time_trial	36 (36, 36)	36 (19, 36)	36 (19, 36)	30 (15, 36)	29 (15, 36)
	time_stop	NA (NA, NA)	23 (13, 33)	23 (15, 34)	22 (14, 33)	21 (13, 34)
	post_p	NA (NA, NA)	0.27 (0.05, 0.73)	0.3 (0.03, 0.7)	1 (1, 1)	1 (1, 1)
	rate	0.113 (0.097, 0.131)	0.115 (0.093, 0.141)	0.113 (0.094, 0.141)	0.036 (0.028, 0.046)	0.036 (0.026, 0.045)
TEfus+	graduation	0	4	2	24	24
	futility	0	64	45	1	2
	max_n	0	1	0	0	0
	n	105 (88, 126)	81 (39, 108)	87 (53, 112)	81 (57, 107)	82 (56, 108)
	n_unique	96 (80, 116)	75 (36, 98)	80 (49, 103)	74 (52, 98)	75 (49, 98)
	time_trial	36 (36, 36)	36 (25, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	15 (11, 32)	20 (12, 30)	15 (10, 27)	14 (10, 24)
	post_p	NA (NA, NA)	0.41 (0.06, 0.82)	0.42 (0.09, 0.86)	0.99 (0.86, 1)	0.99 (0.83, 1)
	rate	0.112 (0.099, 0.13)	0.114 (0.096, 0.139)	0.112 (0.095, 0.133)	0.074 (0.061, 0.089)	0.074 (0.06, 0.089)

By subgroup combinations:

subtype	var	Control	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
—-	graduation	0	218	231	152	165
	futility	0	0	0	0	0
	max_n	0	7	6	6	15
	n	71 (55, 92)	56 (17, 75)	54 (18, 78)	62 (21, 83)	60 (19, 82)
	n_unique	65 (51, 85)	53 (16, 72)	52 (17, 73)	58 (19, 78)	56 (17, 77)
	post_p	NA (NA, NA)	0.49 (0.11, 0.88)	0.46 (0.1, 0.87)	0.54 (0.14, 0.88)	0.55 (0.11, 0.86)
	rate	0.113 (0.094, 0.134)	0.113 (0.094, 0.144)	0.115 (0.093, 0.147)	0.112 (0.093, 0.134)	0.112 (0.092, 0.135)
—+	graduation	0	241	248	165	178
	futility	0	0	0	0	0
	max_n	0	8	6	6	15
	n	15 (10, 22)	10 (3, 17)	10 (3, 19)	12 (3, 19)	12 (3, 19)
	n_unique	14 (8, 20)	9 (3, 16)	9 (3, 17)	11 (3, 18)	10 (3, 17)
	post_p	NA (NA, NA)	0.5 (0.18, 0.82)	0.47 (0.18, 0.84)	0.52 (0.18, 0.84)	0.52 (0.19, 0.82)
	rate	0.115 (0.078, 0.172)	0.117 (0.078, 0.212)	0.117 (0.079, 0.22)	0.11 (0.072, 0.17)	0.112 (0.07, 0.17)
–+-	graduation	0	88	58	40	44
	futility	0	0	0	0	0
	max_n	0	7	17	4	9
	n	37 (29, 47)	34 (15, 44)	35 (23, 44)	35 (26, 45)	36 (25, 45)
	n_unique	34 (26, 44)	32 (15, 41)	32 (21, 42)	33 (24, 42)	33 (23, 42)
	post_p	NA (NA, NA)	0.5 (0.13, 0.85)	0.52 (0.16, 0.88)	0.53 (0.16, 0.88)	0.49 (0.14, 0.87)
	rate	0.114 (0.089, 0.143)	0.115 (0.09, 0.153)	0.113 (0.089, 0.146)	0.113 (0.088, 0.143)	0.115 (0.087, 0.145)
–++	graduation	0	139	92	59	63
	futility	0	0	0	0	0
	max_n	0	7	17	4	9
	n	25 (19, 35)	22 (8, 31)	23 (12, 32)	24 (15, 32)	24 (14, 32)
	n_unique	23 (16, 32)	21 (7, 28)	21 (11, 29)	22 (14, 30)	22 (13, 30)
	post_p	NA (NA, NA)	0.47 (0.15, 0.84)	0.51 (0.16, 0.86)	0.5 (0.15, 0.86)	0.53 (0.14, 0.84)
	rate	0.113 (0.084, 0.152)	0.118 (0.084, 0.167)	0.112 (0.086, 0.156)	0.113 (0.083, 0.152)	0.112 (0.083, 0.151)
-+–	graduation	0	302	299	378	373
	futility	0	0	0	0	0
	max_n	0	7	6	6	12
	n	16 (9, 23)	10 (3, 20)	10 (3, 19)	9 (3, 17)	9 (3, 17)
	n_unique	14 (9, 21)	9 (3, 18)	9 (3, 18)	8 (3, 16)	8 (3, 16)
	post_p	NA (NA, NA)	0.3 (0.09, 0.66)	0.31 (0.08, 0.62)	0.94 (0.75, 0.99)	0.94 (0.71, 1)
	rate	0.114 (0.079, 0.168)	0.119 (0.077, 0.206)	0.119 (0.078, 0.227)	0.036 (0.017, 0.063)	0.036 (0.015, 0.067)
-+-+	graduation	0	316	309	383	376
	futility	0	0	0	0	0
	max_n	0	8	6	6	12
	n	16 (10, 23)	9 (3, 20)	10 (3, 20)	9 (3, 17)	8 (3, 18)
	n_unique	15 (9, 22)	8 (2, 18)	9 (3, 18)	8 (2, 16)	8 (3, 16)
	post_p	NA (NA, NA)	0.31 (0.08, 0.63)	0.3 (0.1, 0.65)	0.93 (0.71, 0.99)	0.94 (0.72, 1)
	rate	0.111 (0.078, 0.166)	0.121 (0.076, 0.222)	0.117 (0.076, 0.211)	0.037 (0.016, 0.066)	0.036 (0.016, 0.062)
-++-	graduation	0	232	193	340	328
	futility	0	0	0	0	0
	max_n	0	6	17	2	9
	n	9 (5, 13)	7 (2, 12)	7 (3, 13)	5 (2, 10)	6 (2, 11)
	n_unique	8 (4, 12)	6 (2, 11)	6 (2, 12)	5 (1, 9)	5 (2, 11)
	post_p	NA (NA, NA)	0.32 (0.11, 0.63)	0.32 (0.11, 0.64)	0.84 (0.59, 0.97)	0.87 (0.59, 0.98)
	rate	0.118 (0.072, 0.192)	0.123 (0.072, 0.242)	0.119 (0.072, 0.217)	0.037 (0.014, 0.085)	0.034 (0.014, 0.072)
-+++	graduation	0	259	210	346	334
	futility	0	0	0	0	0
	max_n	0	6	17	2	9
	n	9 (5, 13)	6 (1, 11)	7 (2, 13)	5 (2, 11)	6 (2, 11)
	n_unique	8 (4, 12)	6 (1, 10)	6 (2, 12)	5 (2, 10)	5 (2, 10)
	post_p	NA (NA, NA)	0.33 (0.12, 0.63)	0.34 (0.1, 0.62)	0.86 (0.59, 0.97)	0.85 (0.59, 0.98)
	rate	0.115 (0.07, 0.194)	0.121 (0.069, 0.256)	0.118 (0.065, 0.219)	0.035 (0.015, 0.073)	0.034 (0.013, 0.072)
+—	graduation	0	10	6	14	19
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	12 (8, 17)	12 (8, 17)	12 (8, 17)	12 (7, 17)	12 (7, 17)
	n_unique	11 (7, 16)	11 (6, 16)	11 (7, 16)	11 (6, 16)	11 (6, 16)
	post_p	NA (NA, NA)	0.49 (0.18, 0.82)	0.52 (0.18, 0.85)	0.48 (0.16, 0.86)	0.5 (0.15, 0.81)
	rate	0.114 (0.073, 0.171)	0.115 (0.075, 0.176)	0.113 (0.074, 0.177)	0.116 (0.072, 0.182)	0.116 (0.076, 0.182)
+–+	graduation	0	76	51	38	43
	futility	0	0	0	0	0
	max_n	0	1	0	0	0
	n	10 (6, 14)	9 (4, 14)	9 (5, 14)	9 (5, 14)	9 (5, 14)
	n_unique	9 (5, 13)	8 (4, 13)	8 (4, 13)	8 (5, 13)	8 (4, 13)
	post_p	NA (NA, NA)	0.48 (0.19, 0.8)	0.51 (0.18, 0.85)	0.5 (0.18, 0.81)	0.5 (0.17, 0.83)
	rate	0.115 (0.071, 0.186)	0.117 (0.077, 0.202)	0.112 (0.068, 0.193)	0.113 (0.071, 0.192)	0.115 (0.069, 0.185)
+-+-	graduation	0	88	58	40	44
	futility	0	0	0	0	0
	max_n	0	7	17	4	9
	n	10 (6, 14)	9 (4, 13)	9 (5, 14)	10 (5, 14)	10 (5, 14)
	n_unique	9 (5, 13)	8 (4, 12)	9 (4, 13)	9 (5, 13)	9 (5, 13)
	post_p	NA (NA, NA)	0.48 (0.15, 0.78)	0.5 (0.18, 0.82)	0.5 (0.18, 0.82)	0.52 (0.17, 0.81)
	rate	0.11 (0.069, 0.179)	0.118 (0.073, 0.215)	0.115 (0.071, 0.19)	0.112 (0.068, 0.201)	0.116 (0.07, 0.184)
+-++	graduation	0	139	92	59	63
	futility	0	0	0	0	0
	max_n	0	7	17	4	9
	n	10 (6, 16)	9 (3, 14)	9 (4, 15)	9 (4, 15)	10 (4, 14)
	n_unique	10 (6, 15)	8 (2, 13)	9 (3, 14)	8 (4, 13)	8 (4, 13)
	post_p	NA (NA, NA)	0.48 (0.17, 0.82)	0.53 (0.16, 0.83)	0.5 (0.19, 0.82)	0.51 (0.18, 0.82)
	rate	0.114 (0.075, 0.183)	0.121 (0.073, 0.212)	0.112 (0.069, 0.204)	0.115 (0.066, 0.197)	0.113 (0.066, 0.192)
++–	graduation	0	182	164	331	327
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	9 (5, 13)	7 (2, 12)	7 (3, 12)	5 (2, 11)	6 (2, 11)
	n_unique	8 (4, 12)	6 (2, 11)	7 (2, 11)	5 (2, 10)	5 (2, 9)
	post_p	NA (NA, NA)	0.34 (0.1, 0.62)	0.34 (0.11, 0.62)	0.84 (0.55, 0.97)	0.85 (0.55, 0.97)
	rate	0.117 (0.07, 0.191)	0.118 (0.07, 0.232)	0.118 (0.067, 0.223)	0.039 (0.012, 0.079)	0.039 (0.011, 0.078)
++-+	graduation	0	216	186	339	334
	futility	0	0	0	0	0
	max_n	0	1	0	0	0
	n	9 (5, 13)	7 (2, 12)	7 (3, 12)	5 (2, 11)	5 (2, 11)
	n_unique	8 (4, 12)	6 (2, 11)	7 (3, 12)	5 (2, 10)	5 (2, 9)
	post_p	NA (NA, NA)	0.34 (0.12, 0.63)	0.34 (0.12, 0.65)	0.85 (0.56, 0.98)	0.85 (0.58, 0.97)
	rate	0.116 (0.071, 0.206)	0.121 (0.067, 0.232)	0.116 (0.064, 0.199)	0.037 (0.013, 0.077)	0.037 (0.014, 0.082)
+++-	graduation	0	232	193	340	328
	futility	0	0	0	0	0
	max_n	0	6	17	2	9
	n	9 (5, 14)	6 (2, 11)	7 (2, 11)	5 (2, 10)	5 (2, 11)
	n_unique	8 (4, 13)	6 (2, 10)	6 (2, 11)	4 (2, 9)	5 (1, 10)
	post_p	NA (NA, NA)	0.35 (0.13, 0.65)	0.33 (0.11, 0.66)	0.83 (0.56, 0.97)	0.86 (0.55, 0.97)
	rate	0.119 (0.068, 0.197)	0.12 (0.064, 0.228)	0.116 (0.067, 0.215)	0.036 (0.014, 0.079)	0.036 (0.012, 0.077)
++++	graduation	0	259	210	346	334
	futility	0	0	0	0	0
	max_n	0	6	17	2	9
	n	9 (5, 14)	6 (2, 13)	7 (2, 12)	5 (2, 10)	5 (2, 11)
	n_unique	8 (5, 13)	6 (1, 11)	6 (2, 11)	5 (1, 9)	5 (1, 10)
	post_p	NA (NA, NA)	0.34 (0.12, 0.64)	0.32 (0.11, 0.62)	0.85 (0.52, 0.98)	0.85 (0.59, 0.97)
	rate	0.114 (0.067, 0.209)	0.122 (0.068, 0.242)	0.121 (0.07, 0.248)	0.038 (0.012, 0.085)	0.038 (0.013, 0.077)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	count	4	2	13	19
	time_stop	4 (4, 5)	4 (4, 4)	15 (6, 28)	22 (5, 34)
	n_trt	26 (25, 28)	29 (28, 30)	87 (36, 178)	107 (31, 182)
	n_control	26 (18, 31)	25 (23, 27)	102 (40, 214)	156 (30, 254)
	post_p	0.89 (0.85, 0.92)	0.91 (0.88, 0.93)	0.99 (0.96, 1)	1 (0.97, 1)
	order	1 (1, 1)	1 (1, 1)	1 (1, 3.8)	3 (1, 4)
TP53- & AR-	count	9	11	134	151
	time_stop	12 (10, 14)	12 (10, 19)	18 (9, 29)	15 (9, 30)
	n_trt	33 (27, 38)	27 (25, 43)	48 (26, 92)	40 (26, 86)
	n_control	32 (25, 43)	36 (26, 57)	51 (22, 90)	44 (24, 91)
	post_p	0.93 (0.88, 0.97)	0.93 (0.86, 0.97)	0.96 (0.9, 1)	0.97 (0.9, 1)
	order	1 (1, 2)	2 (1, 3)	2 (1, 3)	1 (1, 3)
TP53+	count	6	5	25	27
	time_stop	8 (7, 9)	10 (9, 11)	18 (9, 27)	16 (10, 29)
	n_trt	26 (25, 29)	30 (27, 33)	46 (25, 78)	48 (27, 86)
	n_control	20 (20, 26)	35 (28, 38)	57 (23, 93)	52 (27, 96)
	post_p	0.93 (0.9, 0.97)	0.96 (0.94, 0.97)	0.99 (0.94, 1)	0.98 (0.96, 1)
	order	1 (1, 1)	2 (1, 2)	2 (1, 4)	2 (1, 3)
DRD+	count			322	321
	time_stop			22 (14, 33)	21 (13, 34)
	n_trt			39 (25, 74)	37 (26, 69)
	n_control			45 (24, 79)	43 (25, 74)
	post_p			1 (0.99, 1)	1 (0.99, 1)
	order			2 (1, 3)	2 (1, 3)
TEfus+	count	4	2	24	24
	time_stop	13 (9, 16)	12 (12, 13)	14 (10, 28)	15 (10, 24)
	n_trt	30 (26, 40)	26 (25, 28)	32 (27, 53)	30 (25, 51)
	n_control	28 (23, 50)	34 (32, 36)	40 (23, 75)	40 (27, 72)
	post_p	0.94 (0.87, 0.97)	0.95 (0.91, 0.99)	0.98 (0.92, 1)	1 (0.96, 1)
	order	1.5 (1, 2.7)	2.5 (1.3, 3.7)	2 (1, 3)	2 (1, 3)

Futility:

signature	var	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	count	6	4	1
	time_stop	13 (6, 25)	14 (4, 28)	4 (4, 4)
	n_trt	65 (40, 142)	77 (29, 153)	30 (30, 30)
	n_control	94 (37, 196)	110 (29, 236)	29 (29, 29)
	post_p	0.05 (0.02, 0.17)	0.03 (0.01, 0.09)	0.09 (0.09, 0.09)
	order	2 (1, 3.5)	3.5 (1, 6)	1 (1, 1)
TP53- & AR-	count	203	216	9	6
	time_stop	17 (10, 30)	17 (10, 31)	10 (9, 14)	11 (10, 18)
	n_trt	43 (26, 86)	44 (26, 92)	26 (25, 32)	27 (26, 42)
	n_control	46 (23, 95)	46 (24, 100)	28 (24, 37)	32 (24, 46)
	post_p	0.16 (0.05, 0.26)	0.16 (0.04, 0.28)	0.16 (0.03, 0.23)	0.18 (0.09, 0.25)
	order	1 (1, 3)	1 (1, 3)	1 (1, 1.2)	1 (1, 3)
TP53+	count	75	49	2	1
	time_stop	18 (9, 30)	19 (9, 32)	11 (11, 11)	8 (8, 8)
	n_trt	47 (28, 96)	59 (27, 100)	28 (26, 31)	28 (28, 28)
	n_control	49 (26, 102)	58 (25, 104)	34 (32, 37)	13 (13, 13)
	post_p	0.09 (0.02, 0.19)	0.09 (0.02, 0.19)	0.1 (0.07, 0.13)	0.21 (0.21, 0.21)
	order	2 (1, 3)	2 (1, 3)	1 (1, 1)	1 (1, 1)
DRD+	count	173	160
	time_stop	23 (13, 33)	23 (15, 34)
	n_trt	41 (26, 68)	42 (26, 71)
	n_control	47 (24, 79)	46 (27, 78)
	post_p	0.08 (0.01, 0.22)	0.08 (0.01, 0.22)
	order	2 (1, 4)	2 (1, 4)
TEfus+	count	64	45	1	2
	time_stop	15 (11, 33)	20 (12, 30)	18 (18, 18)	9 (8, 10)
	n_trt	36 (25, 75)	47 (30, 75)	47 (47, 47)	26 (25, 27)
	n_control	37 (23, 96)	52 (28, 91)	45 (45, 45)	22 (18, 26)
	post_p	0.06 (0, 0.17)	0.07 (0.02, 0.19)	0.08 (0.08, 0.08)	0.05 (0.04, 0.06)
	order	2 (1, 4)	2 (1, 4)	1 (1, 1)	1 (1, 1)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Hormone_therapies	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
		time	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)
		n	7 (6, 9)	0 (0, 2)	4 (2, 5)	2 (1, 4)	0 (0, 1)	1 (1, 2)	0 (0, 1)	0 (0, 2)	0 (0, 2)	2 (0, 2)	1 (1, 2)	2 (0, 3)	0 (0, 2)	1 (0, 2)	2 (1, 2)	0 (0, 2)
		post_p	0.67 (0.56, 0.76)	0.88 (0.88, 0.88)	0.69 (0.63, 0.79)	0.58 (0.56, 0.62)	0.59 (0.57, 0.61)	0.61 (0.55, 0.66)	0.52 (0.52, 0.52)	0.78 (0.78, 0.78)	0.66 (0.61, 0.71)	0.7 (0.67, 0.74)	0.56 (0.56, 0.56)	0.57 (0.57, 0.57)	NA (NA, NA)	0.56 (0.56, 0.56)	0.56 (0.53, 0.59)	0.67 (0.67, 0.67)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.054 (0.015, 0.1)	0.09 (0.09, 0.09)	0 (0, 0.05)	0 (0, 0)	0 (0, 0)	0 (0, 0.303)	0.191 (0.191, 0.191)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1.006)	0 (0, 0.245)	0.227 (0.045, 0.408)	0 (0, 0)	0 (0, 0)	0 (0, 0)
	Taxel_therapies	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
		time	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)
		n	10 (5, 15)	2 (0, 4)	5 (4, 6)	3 (3, 3)	2 (1, 2)	0 (0, 0)	0 (0, 0)	2 (0, 4)	2 (1, 2)	2 (1, 2)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	1 (0, 2)	1 (0, 2)
		post_p	0.64 (0.56, 0.73)	0.66 (0.66, 0.66)	0.67 (0.6, 0.74)	0.52 (0.52, 0.53)	0.65 (0.58, 0.72)	NA (NA, NA)	NA (NA, NA)	0.64 (0.64, 0.64)	0.56 (0.54, 0.57)	0.6 (0.55, 0.66)	0.57 (0.57, 0.57)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.58 (0.58, 0.58)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.013 (0.003, 0.024)	0.116 (0.116, 0.116)	0 (0, 0)	0.055 (0.011, 0.1)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)
	Carboplatin	count	13	13	13	13	13	13	13	13	13	13	13	13	13	13	13	13
		time	15 (6, 28)	15 (6, 28)	15 (6, 28)	15 (6, 28)	15 (6, 28)	15 (6, 28)	15 (6, 28)	15 (6, 28)	15 (6, 28)	15 (6, 28)	15 (6, 28)	15 (6, 28)	15 (6, 28)	15 (6, 28)	15 (6, 28)	15 (6, 28)
		n	14 (8, 40)	5 (1, 10)	13 (6, 29)	6 (2, 24)	3 (1, 8)	3 (1, 9)	3 (0, 7)	3 (0, 7)	5 (1, 12)	3 (1, 8)	4 (0, 7)	3 (0, 8)	2 (0, 6)	2 (0, 6)	3 (0, 6)	3 (1, 6)
		post_p	0.68 (0.52, 0.9)	0.64 (0.53, 0.77)	0.63 (0.53, 0.77)	0.57 (0.52, 0.71)	0.61 (0.51, 0.86)	0.66 (0.52, 0.86)	0.65 (0.53, 0.85)	0.69 (0.53, 0.86)	0.67 (0.55, 0.96)	0.56 (0.51, 0.79)	0.7 (0.56, 0.89)	0.58 (0.55, 0.74)	0.62 (0.58, 0.89)	0.72 (0.56, 0.88)	0.59 (0.52, 0.84)	0.75 (0.56, 0.88)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.085 (0.063, 0.096)	0.071 (0, 0.106)	0.1 (0.05, 0.13)	0.087 (0.008, 0.131)	0.034 (0, 0.097)	0.023 (0, 0.052)	0.015 (0, 0.063)	0.021 (0, 0.072)	0.034 (0, 0.109)	0.087 (0, 0.134)	0.048 (0, 0.071)	0.084 (0, 0.129)	0.011 (0, 0.064)	0 (0, 0.036)	0 (0, 0.078)	0 (0, 0.043)
	Niraparib	count	19	19	19	19	19	19	19	19	19	19	19	19	19	19	19	19
		time	22 (5, 34)	22 (5, 34)	22 (5, 34)	22 (5, 34)	22 (5, 34)	22 (5, 34)	22 (5, 34)	22 (5, 34)	22 (5, 34)	22 (5, 34)	22 (5, 34)	22 (5, 34)	22 (5, 34)	22 (5, 34)	22 (5, 34)	22 (5, 34)
		n	21 (6, 51)	4 (1, 15)	18 (4, 31)	9 (3, 21)	5 (2, 8)	3 (1, 10)	3 (1, 7)	2 (0, 7)	6 (1, 12)	6 (1, 10)	5 (1, 12)	4 (1, 11)	3 (1, 6)	4 (2, 7)	3 (0, 6)	3 (1, 8)
		post_p	0.68 (0.61, 0.82)	0.63 (0.51, 0.77)	0.66 (0.53, 0.87)	0.62 (0.53, 0.82)	0.73 (0.64, 0.94)	0.82 (0.59, 0.94)	0.73 (0.57, 0.9)	0.75 (0.65, 0.93)	0.6 (0.51, 0.74)	0.59 (0.51, 0.8)	0.7 (0.54, 0.83)	0.63 (0.52, 0.9)	0.64 (0.51, 0.93)	0.76 (0.59, 0.9)	0.58 (0.52, 0.94)	0.72 (0.59, 0.86)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.1 (0.053, 0.112)	0.071 (0, 0.105)	0.088 (0.033, 0.11)	0.091 (0.043, 0.118)	0.029 (0, 0.068)	0.036 (0, 0.081)	0.039 (0, 0.079)	0.017 (0, 0.037)	0.089 (0, 0.112)	0.091 (0.023, 0.122)	0.066 (0, 0.13)	0.043 (0, 0.114)	0.023 (0, 0.078)	0.017 (0, 0.051)	0.036 (0, 0.103)	0.018 (0, 0.051)
TP53- & AR-	Hormone_therapies	count	9	9			9	9
		time	12 (10, 14)	12 (10, 14)			12 (10, 14)	12 (10, 14)
		n	18 (16, 25)	4 (3, 5)			4 (2, 5)	4 (2, 10)
		post_p	0.82 (0.8, 0.9)	0.6 (0.51, 0.77)			0.67 (0.53, 0.71)	0.63 (0.54, 0.84)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.079 (0.051, 0.098)	0.058 (0, 0.108)			0.042 (0, 0.114)	0.029 (0, 0.062)
	Taxel_therapies	count	11	11			11	11
		time	12 (10, 19)	12 (10, 19)			12 (10, 19)	12 (10, 19)
		n	19 (14, 30)	3 (2, 6)			3 (2, 5)	4 (3, 5)
		post_p	0.8 (0.74, 0.9)	0.69 (0.51, 0.84)			0.64 (0.53, 0.76)	0.68 (0.56, 0.77)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.087 (0.067, 0.098)	0.048 (0, 0.173)			0 (0, 0.076)	0.053 (0, 0.119)
	Carboplatin	count	134	134			134	134
		time	18 (9, 29)	18 (9, 29)			18 (9, 29)	18 (9, 29)
		n	31 (17, 56)	5 (2, 12)			5 (2, 13)	5 (2, 13)
		post_p	0.77 (0.71, 0.92)	0.71 (0.53, 0.87)			0.78 (0.58, 0.94)	0.78 (0.58, 0.96)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.088 (0.061, 0.115)	0.07 (0, 0.118)			0.031 (0, 0.057)	0.031 (0, 0.061)
	Niraparib	count	151	151			151	151
		time	15 (9, 30)	15 (9, 30)			15 (9, 30)	15 (9, 30)
		n	27 (16, 55)	4 (1, 12)			5 (2, 12)	5 (2, 10)
		post_p	0.76 (0.71, 0.9)	0.7 (0.53, 0.84)			0.8 (0.58, 0.95)	0.78 (0.6, 0.95)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.088 (0.054, 0.11)	0.073 (0, 0.104)			0.025 (0, 0.056)	0.025 (0, 0.059)
TP53+	Hormone_therapies	count			6	6			6	6			6	6			6	6
		time			8 (7, 9)	8 (7, 9)			8 (7, 9)	8 (7, 9)			8 (7, 9)	8 (7, 9)			8 (7, 9)	8 (7, 9)
		n			12 (9, 12)	6 (3, 8)			2 (0, 3)	1 (0, 2)			4 (3, 5)	2 (0, 2)			2 (1, 3)	0 (0, 2)
		post_p			0.82 (0.77, 0.88)	0.72 (0.64, 0.86)			0.53 (0.51, 0.55)	0.65 (0.62, 0.68)			0.7 (0.67, 0.83)	0.54 (0.54, 0.6)			0.52 (0.51, 0.59)	NA (NA, NA)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.042 (0.029, 0.071)	0.022 (0, 0.091)			0 (0, 0)	0 (0, 0)			0.061 (0, 0.155)	0.064 (0, 0.144)			0.08 (0, 0.225)	0 (0, 0.506)
	Taxel_therapies	count			5	5			5	5			5	5			5	5
		time			10 (9, 11)	10 (9, 11)			10 (9, 11)	10 (9, 11)			10 (9, 11)	10 (9, 11)			10 (9, 11)	10 (9, 11)
		n			10 (9, 15)	7 (6, 9)			1 (0, 3)	2 (1, 4)			3 (1, 4)	1 (0, 3)			1 (1, 3)	3 (0, 4)
		post_p			0.79 (0.74, 0.85)	0.72 (0.68, 0.76)			0.53 (0.52, 0.86)	0.55 (0.52, 0.71)			0.77 (0.67, 0.82)	0.84 (0.62, 0.88)			0.58 (0.53, 0.61)	0.55 (0.53, 0.7)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.047 (0.034, 0.053)	0.055 (0.05, 0.085)			0.028 (0.006, 0.127)	0.061 (0, 0.131)			0 (0, 0.042)	0 (0, 0)			0 (0, 0.05)	0.068 (0.051, 0.115)
	Carboplatin	count			25	25			25	25			25	25			25	25
		time			18 (9, 27)	18 (9, 27)			18 (9, 27)	18 (9, 27)			18 (9, 27)	18 (9, 27)			18 (9, 27)	18 (9, 27)
		n			14 (7, 29)	10 (4, 18)			3 (1, 7)	3 (0, 8)			4 (0, 7)	4 (1, 8)			3 (0, 6)	2 (1, 5)
		post_p			0.76 (0.73, 0.88)	0.75 (0.6, 0.85)			0.73 (0.56, 0.92)	0.76 (0.59, 0.93)			0.64 (0.51, 0.77)	0.74 (0.54, 0.86)			0.68 (0.52, 0.91)	0.66 (0.54, 0.9)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.077 (0.033, 0.111)	0.074 (0.014, 0.099)			0.018 (0, 0.072)	0.025 (0, 0.046)			0.077 (0, 0.145)	0.06 (0, 0.107)			0.009 (0, 0.061)	0 (0, 0.091)
	Niraparib	count			27	27			27	27			27	27			27	27
		time			16 (10, 29)	16 (10, 29)			16 (10, 29)	16 (10, 29)			16 (10, 29)	16 (10, 29)			16 (10, 29)	16 (10, 29)
		n			19 (8, 32)	11 (5, 21)			3 (1, 7)	3 (1, 6)			5 (1, 9)	4 (2, 7)			3 (1, 4)	2 (1, 5)
		post_p			0.78 (0.71, 0.88)	0.78 (0.71, 0.87)			0.77 (0.62, 0.94)	0.69 (0.54, 0.84)			0.71 (0.56, 0.87)	0.69 (0.53, 0.83)			0.63 (0.52, 0.81)	0.67 (0.52, 0.91)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.073 (0.032, 0.104)	0.079 (0.036, 0.097)			0.016 (0, 0.048)	0 (0, 0.048)			0.059 (0, 0.105)	0.07 (0, 0.116)			0.016 (0, 0.085)	0 (0, 0.057)
DRD+	Carboplatin	count					322	322	322	322					322	322	322	322
		time					22 (14, 33)	22 (14, 33)	22 (14, 33)	22 (14, 33)					22 (14, 33)	22 (14, 33)	22 (14, 33)	22 (14, 33)
		n					7 (3, 15)	7 (3, 15)	4 (1, 9)	4 (2, 10)					4 (1, 9)	4 (2, 9)	4 (2, 9)	4 (2, 9)
		post_p					0.82 (0.65, 0.98)	0.83 (0.63, 0.97)	0.74 (0.54, 0.93)	0.75 (0.55, 0.92)					0.75 (0.54, 0.93)	0.76 (0.55, 0.92)	0.74 (0.56, 0.92)	0.75 (0.54, 0.93)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.032 (0, 0.059)	0.031 (0, 0.061)	0.03 (0, 0.08)	0.032 (0, 0.069)					0.029 (0, 0.066)	0.028 (0, 0.073)	0.031 (0, 0.067)	0.03 (0, 0.084)
	Niraparib	count					321	321	321	321					321	321	321	321
		time					21 (13, 34)	21 (13, 34)	21 (13, 34)	21 (13, 34)					21 (13, 34)	21 (13, 34)	21 (13, 34)	21 (13, 34)
		n					7 (3, 15)	6 (3, 14)	4 (1, 9)	4 (1, 9)					4 (2, 8)	4 (2, 8)	4 (1, 9)	4 (1, 9)
		post_p					0.82 (0.61, 0.99)	0.85 (0.64, 0.97)	0.75 (0.57, 0.93)	0.76 (0.54, 0.93)					0.74 (0.54, 0.94)	0.74 (0.53, 0.92)	0.74 (0.54, 0.93)	0.75 (0.54, 0.93)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.03 (0, 0.062)	0.031 (0, 0.063)	0.029 (0, 0.069)	0.027 (0, 0.06)					0.028 (0, 0.073)	0.027 (0, 0.068)	0.026 (0, 0.076)	0.029 (0, 0.066)
TEfus+	Hormone_therapies	count		4		4		4		4		4		4		4		4
		time		13 (9, 16)		13 (9, 16)		13 (9, 16)		13 (9, 16)		13 (9, 16)		13 (9, 16)		13 (9, 16)		13 (9, 16)
		n		5 (3, 7)		7 (4, 15)		4 (3, 5)		2 (1, 3)		3 (2, 4)		2 (1, 4)		2 (0, 5)		4 (3, 4)
		post_p		0.81 (0.7, 0.86)		0.68 (0.62, 0.81)		0.58 (0.54, 0.65)		0.52 (0.51, 0.56)		0.68 (0.54, 0.87)		0.62 (0.57, 0.67)		0.64 (0.54, 0.73)		0.66 (0.55, 0.74)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.019 (0, 0.059)		0.048 (0.014, 0.083)		0.038 (0.008, 0.085)		0.075 (0.021, 0.101)		0.088 (0.061, 0.137)		0 (0, 0.069)		0.028 (0.006, 0.041)		0.045 (0.011, 0.073)
	Taxel_therapies	count		2		2		2		2		2		2		2		2
		time		12 (12, 13)		12 (12, 13)		12 (12, 13)		12 (12, 13)		12 (12, 13)		12 (12, 13)		12 (12, 13)		12 (12, 13)
		n		6 (5, 6)		10 (9, 12)		2 (1, 4)		1 (1, 1)		4 (3, 4)		2 (0, 3)		2 (1, 2)		0 (0, 1)
		post_p		0.63 (0.53, 0.73)		0.87 (0.86, 0.87)		0.83 (0.83, 0.83)		0.66 (0.65, 0.68)		0.7 (0.7, 0.71)		0.62 (0.62, 0.62)		0.62 (0.61, 0.63)		0.55 (0.55, 0.55)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.06 (0.032, 0.087)		0.061 (0.058, 0.064)		0.119 (0.119, 0.119)		0 (0, 0)		0.103 (0.061, 0.145)		0.052 (0.052, 0.052)		0.04 (0.008, 0.073)		0 (0, 0)
	Carboplatin	count		24		24		24		24		24		24		24		24
		time		14 (10, 28)		14 (10, 28)		14 (10, 28)		14 (10, 28)		14 (10, 28)		14 (10, 28)		14 (10, 28)		14 (10, 28)
		n		4 (2, 11)		11 (6, 17)		3 (1, 7)		2 (0, 5)		4 (3, 7)		2 (1, 6)		3 (1, 4)		3 (1, 7)
		post_p		0.64 (0.52, 0.79)		0.79 (0.72, 0.94)		0.7 (0.55, 0.91)		0.61 (0.53, 0.77)		0.65 (0.54, 0.78)		0.63 (0.52, 0.8)		0.66 (0.53, 0.85)		0.71 (0.58, 0.82)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.072 (0.007, 0.134)		0.068 (0.034, 0.097)		0.006 (0, 0.054)		0 (0, 0.056)		0.07 (0.012, 0.127)		0.048 (0, 0.125)		0.018 (0, 0.077)		0 (0, 0.091)
	Niraparib	count		24		24		24		24		24		24		24		24
		time		15 (10, 24)		15 (10, 24)		15 (10, 24)		15 (10, 24)		15 (10, 24)		15 (10, 24)		15 (10, 24)		15 (10, 24)
		n		4 (1, 6)		8 (4, 17)		5 (1, 9)		3 (1, 5)		3 (2, 7)		4 (2, 7)		3 (2, 6)		2 (1, 5)
		post_p		0.67 (0.54, 0.83)		0.76 (0.7, 0.89)		0.82 (0.63, 0.92)		0.68 (0.53, 0.86)		0.7 (0.56, 0.81)		0.7 (0.54, 0.78)		0.72 (0.53, 0.84)		0.65 (0.54, 0.83)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.055 (0, 0.089)		0.064 (0.035, 0.091)		0 (0, 0.039)		0 (0, 0.075)		0.077 (0, 0.11)		0.07 (0, 0.124)		0.017 (0, 0.069)		0.034 (0, 0.072)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Hormone_therapies	count	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6
		time	13 (6, 25)	13 (6, 25)	13 (6, 25)	13 (6, 25)	13 (6, 25)	13 (6, 25)	13 (6, 25)	13 (6, 25)	13 (6, 25)	13 (6, 25)	13 (6, 25)	13 (6, 25)	13 (6, 25)	13 (6, 25)	13 (6, 25)	13 (6, 25)
		n	19 (12, 28)	4 (2, 6)	8 (4, 26)	5 (4, 13)	3 (2, 6)	2 (0, 8)	1 (0, 4)	2 (0, 7)	3 (2, 6)	4 (0, 6)	4 (1, 9)	2 (0, 8)	2 (0, 7)	2 (0, 5)	2 (0, 6)	3 (0, 4)
		post_p	0.33 (0.05, 0.44)	0.39 (0.31, 0.45)	0.38 (0.24, 0.46)	0.41 (0.31, 0.49)	0.41 (0.27, 0.44)	0.39 (0.16, 0.41)	0.42 (0.19, 0.47)	0.39 (0.32, 0.45)	0.41 (0.29, 0.48)	0.38 (0.27, 0.42)	0.36 (0.1, 0.45)	0.4 (0.34, 0.46)	0.31 (0.23, 0.43)	0.37 (0.24, 0.44)	0.29 (0.24, 0.43)	0.3 (0.24, 0.37)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.124 (0.096, 0.181)	0.137 (0.085, 0.167)	0.149 (0.115, 0.295)	0.128 (0.071, 0.207)	0.118 (0.086, 0.131)	0.164 (0.1, 0.511)	0.129 (0.033, 0.242)	0.112 (0.067, 0.846)	0.18 (0.118, 0.389)	0.142 (0.037, 0.299)	0.168 (0.114, 0.411)	0.134 (0.107, 0.331)	0.163 (0.092, 0.888)	0.146 (0.117, 0.212)	0.204 (0.105, 0.245)	0.118 (0.11, 0.151)
	Taxel_therapies	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
		time	14 (4, 28)	14 (4, 28)	14 (4, 28)	14 (4, 28)	14 (4, 28)	14 (4, 28)	14 (4, 28)	14 (4, 28)	14 (4, 28)	14 (4, 28)	14 (4, 28)	14 (4, 28)	14 (4, 28)	14 (4, 28)	14 (4, 28)	14 (4, 28)
		n	22 (6, 54)	6 (3, 10)	12 (5, 22)	8 (3, 14)	4 (2, 7)	2 (0, 6)	1 (0, 1)	2 (1, 4)	4 (1, 7)	2 (0, 4)	2 (0, 5)	2 (0, 3)	4 (1, 6)	2 (2, 3)	4 (1, 8)	1 (0, 5)
		post_p	0.35 (0.16, 0.46)	0.36 (0.32, 0.44)	0.37 (0.26, 0.47)	0.33 (0.2, 0.46)	0.28 (0.22, 0.39)	0.35 (0.33, 0.36)	0.41 (0.3, 0.48)	0.34 (0.17, 0.42)	0.24 (0.21, 0.41)	0.27 (0.14, 0.38)	0.28 (0.25, 0.39)	0.32 (0.26, 0.36)	0.42 (0.17, 0.45)	0.25 (0.14, 0.4)	0.37 (0.22, 0.43)	0.24 (0.16, 0.32)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.14 (0.106, 0.2)	0.133 (0.097, 0.185)	0.18 (0.128, 0.262)	0.128 (0.112, 0.151)	0.143 (0.113, 0.32)	0.173 (0.123, 3.05)	0.174 (0.035, 1.541)	0.224 (0.027, 0.437)	0.306 (0.262, 0.433)	0.628 (0.361, 1.226)	0.184 (0.136, 0.58)	0.225 (0.162, 0.746)	0.263 (0.138, 0.841)	0.297 (0.02, 0.554)	0.136 (0.118, 0.202)	0.183 (0.165, 0.202)
	Carboplatin	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)
		n	6 (6, 6)	1 (1, 1)	6 (6, 6)	3 (3, 3)	0 (0, 0)	1 (1, 1)	0 (0, 0)	2 (2, 2)	3 (3, 3)	0 (0, 0)	0 (0, 0)	1 (1, 1)	0 (0, 0)	4 (4, 4)	1 (1, 1)	2 (2, 2)
		post_p	0.05 (0.05, 0.05)	0.48 (0.48, 0.48)	0.19 (0.19, 0.19)	0.47 (0.47, 0.47)	NA (NA, NA)	0.22 (0.22, 0.22)	NA (NA, NA)	NA (NA, NA)	0.48 (0.48, 0.48)	NA (NA, NA)	NA (NA, NA)	0.5 (0.5, 0.5)	NA (NA, NA)	0.45 (0.45, 0.45)	NA (NA, NA)	0.43 (0.43, 0.43)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.257 (0.257, 0.257)	0 (0, 0)	0.211 (0.211, 0.211)	0.141 (0.141, 0.141)	NA (NA, NA)	0.955 (0.955, 0.955)	NA (NA, NA)	0 (0, 0)	0.141 (0.141, 0.141)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53- & AR-	Hormone_therapies	count	203	203			203	203
		time	17 (10, 30)	17 (10, 30)			17 (10, 30)	17 (10, 30)
		n	26 (15, 56)	6 (2, 11)			6 (3, 12)	5 (2, 11)
		post_p	0.3 (0.11, 0.46)	0.39 (0.15, 0.48)			0.34 (0.09, 0.48)	0.31 (0.12, 0.47)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.128 (0.102, 0.172)	0.145 (0.096, 0.325)			0.128 (0.079, 0.266)	0.14 (0.085, 0.305)
	Taxel_therapies	count	216	216			216	216
		time	17 (10, 31)	17 (10, 31)			17 (10, 31)	17 (10, 31)
		n	28 (16, 56)	6 (2, 13)			5 (2, 12)	6 (3, 13)
		post_p	0.32 (0.09, 0.47)	0.36 (0.12, 0.48)			0.33 (0.11, 0.47)	0.31 (0.1, 0.47)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.127 (0.104, 0.179)	0.152 (0.095, 0.336)			0.133 (0.079, 0.327)	0.13 (0.081, 0.338)
	Carboplatin	count	9	9			9	9
		time	10 (9, 14)	10 (9, 14)			10 (9, 14)	10 (9, 14)
		n	17 (14, 23)	4 (2, 7)			4 (3, 5)	4 (0, 6)
		post_p	0.22 (0.13, 0.35)	0.35 (0.21, 0.44)			0.43 (0.26, 0.47)	0.44 (0.23, 0.48)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.141 (0.12, 0.183)	0.137 (0.081, 0.524)			0.102 (0.053, 0.146)	0.11 (0.054, 0.204)
	Niraparib	count	6	6			6	6
		time	11 (10, 18)	11 (10, 18)			11 (10, 18)	11 (10, 18)
		n	20 (18, 26)	3 (1, 8)			3 (1, 5)	4 (1, 7)
		post_p	0.34 (0.12, 0.48)	0.3 (0.17, 0.42)			0.41 (0.33, 0.47)	0.45 (0.34, 0.47)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.118 (0.095, 0.162)	0.302 (0.097, 0.358)			0.112 (0.101, 0.801)	0.122 (0.035, 0.172)
TP53+	Hormone_therapies	count			75	75			75	75			75	75			75	75
		time			18 (9, 30)	18 (9, 30)			18 (9, 30)	18 (9, 30)			18 (9, 30)	18 (9, 30)			18 (9, 30)	18 (9, 30)
		n			15 (9, 32)	10 (4, 24)			4 (0, 8)	3 (1, 8)			5 (1, 11)	4 (1, 8)			4 (1, 8)	3 (1, 9)
		post_p			0.33 (0.11, 0.48)	0.35 (0.17, 0.49)			0.33 (0.14, 0.46)	0.33 (0.15, 0.44)			0.35 (0.16, 0.48)	0.36 (0.15, 0.49)			0.33 (0.18, 0.48)	0.35 (0.12, 0.46)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.133 (0.105, 0.198)	0.135 (0.107, 0.23)			0.131 (0.079, 0.334)	0.151 (0.069, 0.417)			0.156 (0.091, 0.35)	0.174 (0.102, 0.352)			0.125 (0.048, 0.316)	0.14 (0.088, 0.344)
	Taxel_therapies	count			49	49			49	49			49	49			49	49
		time			19 (9, 32)	19 (9, 32)			19 (9, 32)	19 (9, 32)			19 (9, 32)	19 (9, 32)			19 (9, 32)	19 (9, 32)
		n			18 (8, 29)	13 (5, 22)			4 (1, 8)	4 (1, 7)			4 (1, 10)	5 (1, 10)			5 (0, 9)	4 (1, 9)
		post_p			0.29 (0.12, 0.47)	0.36 (0.15, 0.48)			0.33 (0.16, 0.45)	0.35 (0.2, 0.47)			0.34 (0.18, 0.45)	0.39 (0.14, 0.48)			0.34 (0.15, 0.48)	0.31 (0.18, 0.46)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.138 (0.11, 0.181)	0.14 (0.108, 0.25)			0.115 (0.063, 0.317)	0.125 (0.081, 0.379)			0.161 (0.11, 0.373)	0.167 (0.088, 0.383)			0.129 (0.06, 0.339)	0.151 (0.097, 0.579)
	Carboplatin	count			2	2			2	2			2	2			2	2
		time			11 (11, 11)	11 (11, 11)			11 (11, 11)	11 (11, 11)			11 (11, 11)	11 (11, 11)			11 (11, 11)	11 (11, 11)
		n			10 (8, 13)	6 (4, 9)			2 (1, 2)	2 (0, 4)			4 (2, 5)	3 (1, 5)			2 (0, 3)	0 (0, 0)
		post_p			0.35 (0.23, 0.47)	0.33 (0.25, 0.41)			0.4 (0.32, 0.48)	0.46 (0.46, 0.46)			0.39 (0.34, 0.44)	0.31 (0.24, 0.38)			0.28 (0.28, 0.28)	NA (NA, NA)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.131 (0.116, 0.146)	0.156 (0.136, 0.176)			14.383 (2.877, 25.889)	0.07 (0.07, 0.07)			0.132 (0.131, 0.133)	0.248 (0.14, 0.356)			0.131 (0.131, 0.131)	NA (NA, NA)
	Niraparib	count			1	1			1	1			1	1			1	1
		time			8 (8, 8)	8 (8, 8)			8 (8, 8)	8 (8, 8)			8 (8, 8)	8 (8, 8)			8 (8, 8)	8 (8, 8)
		n			4 (4, 4)	9 (9, 9)			2 (2, 2)	3 (3, 3)			5 (5, 5)	3 (3, 3)			1 (1, 1)	1 (1, 1)
		post_p			0.25 (0.25, 0.25)	0.28 (0.28, 0.28)			NA (NA, NA)	0.48 (0.48, 0.48)			0.34 (0.34, 0.34)	0.44 (0.44, 0.44)			0.46 (0.46, 0.46)	0.41 (0.41, 0.41)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.287 (0.287, 0.287)	0.176 (0.176, 0.176)			0 (0, 0)	0 (0, 0)			0.106 (0.106, 0.106)	0.155 (0.155, 0.155)			0 (0, 0)	0.257 (0.257, 0.257)
DRD+	Hormone_therapies	count					173	173	173	173					173	173	173	173
		time					23 (13, 33)	23 (13, 33)	23 (13, 33)	23 (13, 33)					23 (13, 33)	23 (13, 33)	23 (13, 33)	23 (13, 33)
		n					7 (3, 14)	7 (3, 13)	5 (2, 9)	4 (1, 9)					5 (2, 9)	4 (2, 8)	4 (1, 8)	5 (1, 9)
		post_p					0.28 (0.11, 0.47)	0.28 (0.09, 0.45)	0.3 (0.11, 0.47)	0.31 (0.13, 0.46)					0.33 (0.13, 0.47)	0.33 (0.12, 0.45)	0.33 (0.14, 0.47)	0.35 (0.14, 0.47)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.131 (0.086, 0.231)	0.139 (0.089, 0.27)	0.136 (0.079, 0.307)	0.144 (0.08, 0.346)					0.125 (0.074, 0.293)	0.133 (0.071, 0.289)	0.127 (0.07, 0.303)	0.14 (0.085, 0.308)
	Taxel_therapies	count					160	160	160	160					160	160	160	160
		time					23 (15, 34)	23 (15, 34)	23 (15, 34)	23 (15, 34)					23 (15, 34)	23 (15, 34)	23 (15, 34)	23 (15, 34)
		n					6 (2, 14)	6 (3, 13)	5 (2, 9)	4 (2, 9)					5 (2, 9)	5 (2, 10)	5 (2, 9)	5 (1, 9)
		post_p					0.3 (0.11, 0.46)	0.3 (0.09, 0.46)	0.34 (0.19, 0.47)	0.3 (0.14, 0.47)					0.34 (0.13, 0.47)	0.32 (0.11, 0.47)	0.32 (0.11, 0.47)	0.3 (0.14, 0.47)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.126 (0.079, 0.354)	0.132 (0.086, 0.252)	0.124 (0.081, 0.277)	0.129 (0.077, 0.289)					0.128 (0.076, 0.341)	0.137 (0.082, 0.334)	0.133 (0.076, 0.313)	0.14 (0.084, 0.366)
TEfus+	Hormone_therapies	count		64		64		64		64		64		64		64		64
		time		15 (11, 33)		15 (11, 33)		15 (11, 33)		15 (11, 33)		15 (11, 33)		15 (11, 33)		15 (11, 33)		15 (11, 33)
		n		5 (3, 11)		10 (6, 23)		5 (2, 10)		3 (1, 8)		4 (2, 8)		4 (1, 9)		3 (1, 7)		3 (1, 7)
		post_p		0.39 (0.13, 0.48)		0.31 (0.13, 0.47)		0.26 (0.09, 0.44)		0.34 (0.13, 0.46)		0.37 (0.17, 0.48)		0.3 (0.09, 0.46)		0.34 (0.19, 0.46)		0.33 (0.19, 0.46)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.145 (0.094, 0.267)		0.146 (0.099, 0.241)		0.157 (0.089, 0.296)		0.154 (0.062, 0.589)		0.165 (0.101, 0.466)		0.177 (0.103, 0.417)		0.146 (0.061, 0.38)		0.145 (0.082, 0.335)
	Taxel_therapies	count		45		45		45		45		45		45		45		45
		time		20 (12, 30)		20 (12, 30)		20 (12, 30)		20 (12, 30)		20 (12, 30)		20 (12, 30)		20 (12, 30)		20 (12, 30)
		n		7 (2, 12)		12 (6, 22)		5 (2, 14)		4 (0, 7)		5 (2, 12)		5 (2, 9)		4 (2, 8)		4 (2, 8)
		post_p		0.4 (0.18, 0.48)		0.37 (0.19, 0.48)		0.31 (0.13, 0.42)		0.35 (0.24, 0.45)		0.32 (0.14, 0.47)		0.38 (0.18, 0.49)		0.32 (0.2, 0.45)		0.34 (0.14, 0.47)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.139 (0.09, 0.283)		0.131 (0.107, 0.185)		0.127 (0.077, 0.364)		0.13 (0.081, 0.367)		0.164 (0.104, 0.431)		0.182 (0.106, 0.264)		0.136 (0.083, 0.386)		0.141 (0.097, 0.313)
	Carboplatin	count		1		1		1		1		1		1		1		1
		time		18 (18, 18)		18 (18, 18)		18 (18, 18)		18 (18, 18)		18 (18, 18)		18 (18, 18)		18 (18, 18)		18 (18, 18)
		n		11 (11, 11)		14 (14, 14)		12 (12, 12)		2 (2, 2)		2 (2, 2)		2 (2, 2)		3 (3, 3)		1 (1, 1)
		post_p		0.24 (0.24, 0.24)		0.19 (0.19, 0.19)		0.4 (0.4, 0.4)		0.5 (0.5, 0.5)		0.43 (0.43, 0.43)		0.16 (0.16, 0.16)		0.4 (0.4, 0.4)		0.35 (0.35, 0.35)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.14 (0.14, 0.14)		0.143 (0.143, 0.143)		0.06 (0.06, 0.06)		0.074 (0.074, 0.074)		0.147 (0.147, 0.147)		0.282 (0.282, 0.282)		0.073 (0.073, 0.073)		0.807 (0.807, 0.807)
	Niraparib	count		2		2		2		2		2		2		2		2
		time		9 (8, 10)		9 (8, 10)		9 (8, 10)		9 (8, 10)		9 (8, 10)		9 (8, 10)		9 (8, 10)		9 (8, 10)
		n		3 (3, 3)		10 (8, 12)		3 (2, 4)		0 (0, 0)		4 (2, 5)		2 (1, 3)		3 (2, 4)		1 (0, 2)
		post_p		0.4 (0.34, 0.46)		0.29 (0.23, 0.34)		0.35 (0.26, 0.45)		NA (NA, NA)		0.28 (0.23, 0.33)		0.41 (0.36, 0.46)		0.25 (0.1, 0.4)		0.47 (0.47, 0.47)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.125 (0.084, 0.166)		0.123 (0.101, 0.146)		0.123 (0.076, 0.17)		NA (NA, NA)		0.344 (0.286, 0.401)		1.454 (0.364, 2.543)		0.267 (0.224, 0.31)		0 (0, 0)