Equal randomization: Carboplatin more effective in the DRD+ biomarker signature (cfr scen 6)
By subgroup:
| subtype | var | Other | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| —- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| —+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| –+- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| –++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| -+– | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| -+-+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| -++- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| -+++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| +— | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +–+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +-+- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +-++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| ++– | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| ++-+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| +++- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| ++++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 |
By signature:
| signature | var | Other | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| all | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.075, shape = 1.05 | scale = 0.075, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 13.1, median = 9.4 | mean = 13.1, median = 9.4 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.49, hr = 0.66 | af = 1.49, hr = 0.66 | |
| TP53- & AR- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.075, shape = 1.05 | scale = 0.075, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 13.1, median = 9.4 | mean = 13.1, median = 9.4 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.49, hr = 0.66 | af = 1.49, hr = 0.66 | |
| TP53+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.075, shape = 1.05 | scale = 0.075, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 13.1, median = 9.4 | mean = 13.1, median = 9.4 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.49, hr = 0.66 | af = 1.49, hr = 0.66 | |
| DRD+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| TEfus+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.075, shape = 1.05 | scale = 0.075, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 13.1, median = 9.4 | mean = 13.1, median = 9.4 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.49, hr = 0.66 | af = 1.49, hr = 0.66 |
|
|
|
|
|
|
The overall error was 0.276.
The corresponding errors separate for the different treatments were:
Hormone_therapies Taxel_therapies Carboplatin Niraparib
0.044 0.036 0.126 0.110
The overall power was 0.872.
The corresponding power separate for the different treatments were:
Hormone_therapies Taxel_therapies Carboplatin Niraparib
0.000 0.000 0.644 0.642
| signature | var | Control | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| all | graduation | 0 | 4 | 2 | 13 | 19 |
| futility | 0 | 6 | 4 | 1 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 278 (246, 321) | 217 (145, 280) | 225 (157, 286) | 227 (164, 275) | 224 (155, 282) | |
| n_unique | 254 (226, 292) | 200 (134, 260) | 208 (143, 266) | 209 (152, 255) | 204 (143, 260) | |
| time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | |
| time_stop | NA (NA, NA) | 6 (4, 21) | 4 (4, 26) | 12 (5, 28) | 22 (5, 34) | |
| post_p | NA (NA, NA) | 0.42 (0.08, 0.85) | 0.46 (0.1, 0.9) | 1 (0.94, 1) | 1 (0.94, 1) | |
| rate | 0.113 (0.102, 0.122) | 0.113 (0.103, 0.126) | 0.112 (0.101, 0.124) | 0.083 (0.073, 0.093) | 0.082 (0.072, 0.093) | |
| TP53- & AR- | graduation | 0 | 9 | 11 | 134 | 151 |
| futility | 0 | 203 | 216 | 9 | 6 | |
| max_n | 0 | 7 | 6 | 6 | 15 | |
| n | 119 (97, 144) | 88 (28, 123) | 90 (28, 126) | 95 (31, 126) | 92 (29, 129) | |
| n_unique | 109 (89, 133) | 83 (27, 115) | 85 (26, 119) | 88 (29, 117) | 86 (26, 120) | |
| time_trial | 36 (36, 36) | 36 (12, 36) | 36 (12, 36) | 36 (14, 36) | 36 (12, 36) | |
| time_stop | NA (NA, NA) | 16 (10, 30) | 17 (10, 31) | 17 (9, 29) | 15 (9, 29) | |
| post_p | NA (NA, NA) | 0.41 (0.09, 0.84) | 0.41 (0.08, 0.84) | 0.95 (0.62, 1) | 0.96 (0.61, 1) | |
| rate | 0.113 (0.099, 0.128) | 0.114 (0.097, 0.14) | 0.114 (0.097, 0.143) | 0.085 (0.07, 0.104) | 0.084 (0.067, 0.102) | |
| TP53+ | graduation | 0 | 6 | 5 | 25 | 27 |
| futility | 0 | 75 | 49 | 2 | 1 | |
| max_n | 0 | 7 | 17 | 4 | 9 | |
| n | 120 (102, 144) | 104 (47, 127) | 108 (70, 133) | 103 (77, 124) | 103 (78, 129) | |
| n_unique | 109 (93, 130) | 95 (43, 117) | 100 (63, 124) | 95 (70, 115) | 95 (71, 118) | |
| time_trial | 36 (36, 36) | 36 (21, 36) | 36 (34, 36) | 36 (36, 36) | 36 (36, 36) | |
| time_stop | NA (NA, NA) | 17 (9, 30) | 18 (9, 31) | 17 (10, 26) | 16 (9, 29) | |
| post_p | NA (NA, NA) | 0.4 (0.1, 0.81) | 0.46 (0.11, 0.86) | 0.96 (0.74, 1) | 0.96 (0.7, 1) | |
| rate | 0.113 (0.099, 0.128) | 0.114 (0.1, 0.135) | 0.113 (0.098, 0.13) | 0.084 (0.071, 0.098) | 0.084 (0.07, 0.099) | |
| DRD+ | graduation | 0 | 0 | 0 | 322 | 321 |
| futility | 0 | 173 | 160 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 85 (67, 107) | 62 (29, 91) | 66 (31, 98) | 53 (26, 85) | 53 (26, 87) | |
| n_unique | 78 (61, 100) | 56 (26, 84) | 60 (28, 90) | 47 (23, 76) | 47 (24, 80) | |
| time_trial | 36 (36, 36) | 36 (19, 36) | 36 (19, 36) | 30 (15, 36) | 29 (15, 36) | |
| time_stop | NA (NA, NA) | 23 (13, 33) | 23 (15, 34) | 22 (14, 33) | 21 (13, 34) | |
| post_p | NA (NA, NA) | 0.27 (0.05, 0.73) | 0.3 (0.03, 0.7) | 1 (1, 1) | 1 (1, 1) | |
| rate | 0.113 (0.097, 0.131) | 0.115 (0.093, 0.141) | 0.113 (0.094, 0.141) | 0.036 (0.028, 0.046) | 0.036 (0.026, 0.045) | |
| TEfus+ | graduation | 0 | 4 | 2 | 24 | 24 |
| futility | 0 | 64 | 45 | 1 | 2 | |
| max_n | 0 | 1 | 0 | 0 | 0 | |
| n | 105 (88, 126) | 81 (39, 108) | 87 (53, 112) | 81 (57, 107) | 82 (56, 108) | |
| n_unique | 96 (80, 116) | 75 (36, 98) | 80 (49, 103) | 74 (52, 98) | 75 (49, 98) | |
| time_trial | 36 (36, 36) | 36 (25, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | |
| time_stop | NA (NA, NA) | 15 (11, 32) | 20 (12, 30) | 15 (10, 27) | 14 (10, 24) | |
| post_p | NA (NA, NA) | 0.41 (0.06, 0.82) | 0.42 (0.09, 0.86) | 0.99 (0.86, 1) | 0.99 (0.83, 1) | |
| rate | 0.112 (0.099, 0.13) | 0.114 (0.096, 0.139) | 0.112 (0.095, 0.133) | 0.074 (0.061, 0.089) | 0.074 (0.06, 0.089) |
| subtype | var | Control | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| —- | graduation | 0 | 218 | 231 | 152 | 165 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 7 | 6 | 6 | 15 | |
| n | 71 (55, 92) | 56 (17, 75) | 54 (18, 78) | 62 (21, 83) | 60 (19, 82) | |
| n_unique | 65 (51, 85) | 53 (16, 72) | 52 (17, 73) | 58 (19, 78) | 56 (17, 77) | |
| post_p | NA (NA, NA) | 0.49 (0.11, 0.88) | 0.46 (0.1, 0.87) | 0.54 (0.14, 0.88) | 0.55 (0.11, 0.86) | |
| rate | 0.113 (0.094, 0.134) | 0.113 (0.094, 0.144) | 0.115 (0.093, 0.147) | 0.112 (0.093, 0.134) | 0.112 (0.092, 0.135) | |
| —+ | graduation | 0 | 241 | 248 | 165 | 178 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 8 | 6 | 6 | 15 | |
| n | 15 (10, 22) | 10 (3, 17) | 10 (3, 19) | 12 (3, 19) | 12 (3, 19) | |
| n_unique | 14 (8, 20) | 9 (3, 16) | 9 (3, 17) | 11 (3, 18) | 10 (3, 17) | |
| post_p | NA (NA, NA) | 0.5 (0.18, 0.82) | 0.47 (0.18, 0.84) | 0.52 (0.18, 0.84) | 0.52 (0.19, 0.82) | |
| rate | 0.115 (0.078, 0.172) | 0.117 (0.078, 0.212) | 0.117 (0.079, 0.22) | 0.11 (0.072, 0.17) | 0.112 (0.07, 0.17) | |
| –+- | graduation | 0 | 88 | 58 | 40 | 44 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 7 | 17 | 4 | 9 | |
| n | 37 (29, 47) | 34 (15, 44) | 35 (23, 44) | 35 (26, 45) | 36 (25, 45) | |
| n_unique | 34 (26, 44) | 32 (15, 41) | 32 (21, 42) | 33 (24, 42) | 33 (23, 42) | |
| post_p | NA (NA, NA) | 0.5 (0.13, 0.85) | 0.52 (0.16, 0.88) | 0.53 (0.16, 0.88) | 0.49 (0.14, 0.87) | |
| rate | 0.114 (0.089, 0.143) | 0.115 (0.09, 0.153) | 0.113 (0.089, 0.146) | 0.113 (0.088, 0.143) | 0.115 (0.087, 0.145) | |
| –++ | graduation | 0 | 139 | 92 | 59 | 63 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 7 | 17 | 4 | 9 | |
| n | 25 (19, 35) | 22 (8, 31) | 23 (12, 32) | 24 (15, 32) | 24 (14, 32) | |
| n_unique | 23 (16, 32) | 21 (7, 28) | 21 (11, 29) | 22 (14, 30) | 22 (13, 30) | |
| post_p | NA (NA, NA) | 0.47 (0.15, 0.84) | 0.51 (0.16, 0.86) | 0.5 (0.15, 0.86) | 0.53 (0.14, 0.84) | |
| rate | 0.113 (0.084, 0.152) | 0.118 (0.084, 0.167) | 0.112 (0.086, 0.156) | 0.113 (0.083, 0.152) | 0.112 (0.083, 0.151) | |
| -+– | graduation | 0 | 302 | 299 | 378 | 373 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 7 | 6 | 6 | 12 | |
| n | 16 (9, 23) | 10 (3, 20) | 10 (3, 19) | 9 (3, 17) | 9 (3, 17) | |
| n_unique | 14 (9, 21) | 9 (3, 18) | 9 (3, 18) | 8 (3, 16) | 8 (3, 16) | |
| post_p | NA (NA, NA) | 0.3 (0.09, 0.66) | 0.31 (0.08, 0.62) | 0.94 (0.75, 0.99) | 0.94 (0.71, 1) | |
| rate | 0.114 (0.079, 0.168) | 0.119 (0.077, 0.206) | 0.119 (0.078, 0.227) | 0.036 (0.017, 0.063) | 0.036 (0.015, 0.067) | |
| -+-+ | graduation | 0 | 316 | 309 | 383 | 376 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 8 | 6 | 6 | 12 | |
| n | 16 (10, 23) | 9 (3, 20) | 10 (3, 20) | 9 (3, 17) | 8 (3, 18) | |
| n_unique | 15 (9, 22) | 8 (2, 18) | 9 (3, 18) | 8 (2, 16) | 8 (3, 16) | |
| post_p | NA (NA, NA) | 0.31 (0.08, 0.63) | 0.3 (0.1, 0.65) | 0.93 (0.71, 0.99) | 0.94 (0.72, 1) | |
| rate | 0.111 (0.078, 0.166) | 0.121 (0.076, 0.222) | 0.117 (0.076, 0.211) | 0.037 (0.016, 0.066) | 0.036 (0.016, 0.062) | |
| -++- | graduation | 0 | 232 | 193 | 340 | 328 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 6 | 17 | 2 | 9 | |
| n | 9 (5, 13) | 7 (2, 12) | 7 (3, 13) | 5 (2, 10) | 6 (2, 11) | |
| n_unique | 8 (4, 12) | 6 (2, 11) | 6 (2, 12) | 5 (1, 9) | 5 (2, 11) | |
| post_p | NA (NA, NA) | 0.32 (0.11, 0.63) | 0.32 (0.11, 0.64) | 0.84 (0.59, 0.97) | 0.87 (0.59, 0.98) | |
| rate | 0.118 (0.072, 0.192) | 0.123 (0.072, 0.242) | 0.119 (0.072, 0.217) | 0.037 (0.014, 0.085) | 0.034 (0.014, 0.072) | |
| -+++ | graduation | 0 | 259 | 210 | 346 | 334 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 6 | 17 | 2 | 9 | |
| n | 9 (5, 13) | 6 (1, 11) | 7 (2, 13) | 5 (2, 11) | 6 (2, 11) | |
| n_unique | 8 (4, 12) | 6 (1, 10) | 6 (2, 12) | 5 (2, 10) | 5 (2, 10) | |
| post_p | NA (NA, NA) | 0.33 (0.12, 0.63) | 0.34 (0.1, 0.62) | 0.86 (0.59, 0.97) | 0.85 (0.59, 0.98) | |
| rate | 0.115 (0.07, 0.194) | 0.121 (0.069, 0.256) | 0.118 (0.065, 0.219) | 0.035 (0.015, 0.073) | 0.034 (0.013, 0.072) | |
| +— | graduation | 0 | 10 | 6 | 14 | 19 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 12 (8, 17) | 12 (8, 17) | 12 (8, 17) | 12 (7, 17) | 12 (7, 17) | |
| n_unique | 11 (7, 16) | 11 (6, 16) | 11 (7, 16) | 11 (6, 16) | 11 (6, 16) | |
| post_p | NA (NA, NA) | 0.49 (0.18, 0.82) | 0.52 (0.18, 0.85) | 0.48 (0.16, 0.86) | 0.5 (0.15, 0.81) | |
| rate | 0.114 (0.073, 0.171) | 0.115 (0.075, 0.176) | 0.113 (0.074, 0.177) | 0.116 (0.072, 0.182) | 0.116 (0.076, 0.182) | |
| +–+ | graduation | 0 | 76 | 51 | 38 | 43 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 1 | 0 | 0 | 0 | |
| n | 10 (6, 14) | 9 (4, 14) | 9 (5, 14) | 9 (5, 14) | 9 (5, 14) | |
| n_unique | 9 (5, 13) | 8 (4, 13) | 8 (4, 13) | 8 (5, 13) | 8 (4, 13) | |
| post_p | NA (NA, NA) | 0.48 (0.19, 0.8) | 0.51 (0.18, 0.85) | 0.5 (0.18, 0.81) | 0.5 (0.17, 0.83) | |
| rate | 0.115 (0.071, 0.186) | 0.117 (0.077, 0.202) | 0.112 (0.068, 0.193) | 0.113 (0.071, 0.192) | 0.115 (0.069, 0.185) | |
| +-+- | graduation | 0 | 88 | 58 | 40 | 44 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 7 | 17 | 4 | 9 | |
| n | 10 (6, 14) | 9 (4, 13) | 9 (5, 14) | 10 (5, 14) | 10 (5, 14) | |
| n_unique | 9 (5, 13) | 8 (4, 12) | 9 (4, 13) | 9 (5, 13) | 9 (5, 13) | |
| post_p | NA (NA, NA) | 0.48 (0.15, 0.78) | 0.5 (0.18, 0.82) | 0.5 (0.18, 0.82) | 0.52 (0.17, 0.81) | |
| rate | 0.11 (0.069, 0.179) | 0.118 (0.073, 0.215) | 0.115 (0.071, 0.19) | 0.112 (0.068, 0.201) | 0.116 (0.07, 0.184) | |
| +-++ | graduation | 0 | 139 | 92 | 59 | 63 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 7 | 17 | 4 | 9 | |
| n | 10 (6, 16) | 9 (3, 14) | 9 (4, 15) | 9 (4, 15) | 10 (4, 14) | |
| n_unique | 10 (6, 15) | 8 (2, 13) | 9 (3, 14) | 8 (4, 13) | 8 (4, 13) | |
| post_p | NA (NA, NA) | 0.48 (0.17, 0.82) | 0.53 (0.16, 0.83) | 0.5 (0.19, 0.82) | 0.51 (0.18, 0.82) | |
| rate | 0.114 (0.075, 0.183) | 0.121 (0.073, 0.212) | 0.112 (0.069, 0.204) | 0.115 (0.066, 0.197) | 0.113 (0.066, 0.192) | |
| ++– | graduation | 0 | 182 | 164 | 331 | 327 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 9 (5, 13) | 7 (2, 12) | 7 (3, 12) | 5 (2, 11) | 6 (2, 11) | |
| n_unique | 8 (4, 12) | 6 (2, 11) | 7 (2, 11) | 5 (2, 10) | 5 (2, 9) | |
| post_p | NA (NA, NA) | 0.34 (0.1, 0.62) | 0.34 (0.11, 0.62) | 0.84 (0.55, 0.97) | 0.85 (0.55, 0.97) | |
| rate | 0.117 (0.07, 0.191) | 0.118 (0.07, 0.232) | 0.118 (0.067, 0.223) | 0.039 (0.012, 0.079) | 0.039 (0.011, 0.078) | |
| ++-+ | graduation | 0 | 216 | 186 | 339 | 334 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 1 | 0 | 0 | 0 | |
| n | 9 (5, 13) | 7 (2, 12) | 7 (3, 12) | 5 (2, 11) | 5 (2, 11) | |
| n_unique | 8 (4, 12) | 6 (2, 11) | 7 (3, 12) | 5 (2, 10) | 5 (2, 9) | |
| post_p | NA (NA, NA) | 0.34 (0.12, 0.63) | 0.34 (0.12, 0.65) | 0.85 (0.56, 0.98) | 0.85 (0.58, 0.97) | |
| rate | 0.116 (0.071, 0.206) | 0.121 (0.067, 0.232) | 0.116 (0.064, 0.199) | 0.037 (0.013, 0.077) | 0.037 (0.014, 0.082) | |
| +++- | graduation | 0 | 232 | 193 | 340 | 328 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 6 | 17 | 2 | 9 | |
| n | 9 (5, 14) | 6 (2, 11) | 7 (2, 11) | 5 (2, 10) | 5 (2, 11) | |
| n_unique | 8 (4, 13) | 6 (2, 10) | 6 (2, 11) | 4 (2, 9) | 5 (1, 10) | |
| post_p | NA (NA, NA) | 0.35 (0.13, 0.65) | 0.33 (0.11, 0.66) | 0.83 (0.56, 0.97) | 0.86 (0.55, 0.97) | |
| rate | 0.119 (0.068, 0.197) | 0.12 (0.064, 0.228) | 0.116 (0.067, 0.215) | 0.036 (0.014, 0.079) | 0.036 (0.012, 0.077) | |
| ++++ | graduation | 0 | 259 | 210 | 346 | 334 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 6 | 17 | 2 | 9 | |
| n | 9 (5, 14) | 6 (2, 13) | 7 (2, 12) | 5 (2, 10) | 5 (2, 11) | |
| n_unique | 8 (5, 13) | 6 (1, 11) | 6 (2, 11) | 5 (1, 9) | 5 (1, 10) | |
| post_p | NA (NA, NA) | 0.34 (0.12, 0.64) | 0.32 (0.11, 0.62) | 0.85 (0.52, 0.98) | 0.85 (0.59, 0.97) | |
| rate | 0.114 (0.067, 0.209) | 0.122 (0.068, 0.242) | 0.121 (0.07, 0.248) | 0.038 (0.012, 0.085) | 0.038 (0.013, 0.077) |
Posterior probabilities
Randomization probabilities
PFS rates
Posterior probabilities
Randomization probabilities
PFS rates
| signature | var | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|
| all | count | 4 | 2 | 13 | 19 |
| time_stop | 4 (4, 5) | 4 (4, 4) | 15 (6, 28) | 22 (5, 34) | |
| n_trt | 26 (25, 28) | 29 (28, 30) | 87 (36, 178) | 107 (31, 182) | |
| n_control | 26 (18, 31) | 25 (23, 27) | 102 (40, 214) | 156 (30, 254) | |
| post_p | 0.89 (0.85, 0.92) | 0.91 (0.88, 0.93) | 0.99 (0.96, 1) | 1 (0.97, 1) | |
| order | 1 (1, 1) | 1 (1, 1) | 1 (1, 3.8) | 3 (1, 4) | |
| TP53- & AR- | count | 9 | 11 | 134 | 151 |
| time_stop | 12 (10, 14) | 12 (10, 19) | 18 (9, 29) | 15 (9, 30) | |
| n_trt | 33 (27, 38) | 27 (25, 43) | 48 (26, 92) | 40 (26, 86) | |
| n_control | 32 (25, 43) | 36 (26, 57) | 51 (22, 90) | 44 (24, 91) | |
| post_p | 0.93 (0.88, 0.97) | 0.93 (0.86, 0.97) | 0.96 (0.9, 1) | 0.97 (0.9, 1) | |
| order | 1 (1, 2) | 2 (1, 3) | 2 (1, 3) | 1 (1, 3) | |
| TP53+ | count | 6 | 5 | 25 | 27 |
| time_stop | 8 (7, 9) | 10 (9, 11) | 18 (9, 27) | 16 (10, 29) | |
| n_trt | 26 (25, 29) | 30 (27, 33) | 46 (25, 78) | 48 (27, 86) | |
| n_control | 20 (20, 26) | 35 (28, 38) | 57 (23, 93) | 52 (27, 96) | |
| post_p | 0.93 (0.9, 0.97) | 0.96 (0.94, 0.97) | 0.99 (0.94, 1) | 0.98 (0.96, 1) | |
| order | 1 (1, 1) | 2 (1, 2) | 2 (1, 4) | 2 (1, 3) | |
| DRD+ | count | 322 | 321 | ||
| time_stop | 22 (14, 33) | 21 (13, 34) | |||
| n_trt | 39 (25, 74) | 37 (26, 69) | |||
| n_control | 45 (24, 79) | 43 (25, 74) | |||
| post_p | 1 (0.99, 1) | 1 (0.99, 1) | |||
| order | 2 (1, 3) | 2 (1, 3) | |||
| TEfus+ | count | 4 | 2 | 24 | 24 |
| time_stop | 13 (9, 16) | 12 (12, 13) | 14 (10, 28) | 15 (10, 24) | |
| n_trt | 30 (26, 40) | 26 (25, 28) | 32 (27, 53) | 30 (25, 51) | |
| n_control | 28 (23, 50) | 34 (32, 36) | 40 (23, 75) | 40 (27, 72) | |
| post_p | 0.94 (0.87, 0.97) | 0.95 (0.91, 0.99) | 0.98 (0.92, 1) | 1 (0.96, 1) | |
| order | 1.5 (1, 2.7) | 2.5 (1.3, 3.7) | 2 (1, 3) | 2 (1, 3) |
| signature | var | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|
| all | count | 6 | 4 | 1 | |
| time_stop | 13 (6, 25) | 14 (4, 28) | 4 (4, 4) | ||
| n_trt | 65 (40, 142) | 77 (29, 153) | 30 (30, 30) | ||
| n_control | 94 (37, 196) | 110 (29, 236) | 29 (29, 29) | ||
| post_p | 0.05 (0.02, 0.17) | 0.03 (0.01, 0.09) | 0.09 (0.09, 0.09) | ||
| order | 2 (1, 3.5) | 3.5 (1, 6) | 1 (1, 1) | ||
| TP53- & AR- | count | 203 | 216 | 9 | 6 |
| time_stop | 17 (10, 30) | 17 (10, 31) | 10 (9, 14) | 11 (10, 18) | |
| n_trt | 43 (26, 86) | 44 (26, 92) | 26 (25, 32) | 27 (26, 42) | |
| n_control | 46 (23, 95) | 46 (24, 100) | 28 (24, 37) | 32 (24, 46) | |
| post_p | 0.16 (0.05, 0.26) | 0.16 (0.04, 0.28) | 0.16 (0.03, 0.23) | 0.18 (0.09, 0.25) | |
| order | 1 (1, 3) | 1 (1, 3) | 1 (1, 1.2) | 1 (1, 3) | |
| TP53+ | count | 75 | 49 | 2 | 1 |
| time_stop | 18 (9, 30) | 19 (9, 32) | 11 (11, 11) | 8 (8, 8) | |
| n_trt | 47 (28, 96) | 59 (27, 100) | 28 (26, 31) | 28 (28, 28) | |
| n_control | 49 (26, 102) | 58 (25, 104) | 34 (32, 37) | 13 (13, 13) | |
| post_p | 0.09 (0.02, 0.19) | 0.09 (0.02, 0.19) | 0.1 (0.07, 0.13) | 0.21 (0.21, 0.21) | |
| order | 2 (1, 3) | 2 (1, 3) | 1 (1, 1) | 1 (1, 1) | |
| DRD+ | count | 173 | 160 | ||
| time_stop | 23 (13, 33) | 23 (15, 34) | |||
| n_trt | 41 (26, 68) | 42 (26, 71) | |||
| n_control | 47 (24, 79) | 46 (27, 78) | |||
| post_p | 0.08 (0.01, 0.22) | 0.08 (0.01, 0.22) | |||
| order | 2 (1, 4) | 2 (1, 4) | |||
| TEfus+ | count | 64 | 45 | 1 | 2 |
| time_stop | 15 (11, 33) | 20 (12, 30) | 18 (18, 18) | 9 (8, 10) | |
| n_trt | 36 (25, 75) | 47 (30, 75) | 47 (47, 47) | 26 (25, 27) | |
| n_control | 37 (23, 96) | 52 (28, 91) | 45 (45, 45) | 22 (18, 26) | |
| post_p | 0.06 (0, 0.17) | 0.07 (0.02, 0.19) | 0.08 (0.08, 0.08) | 0.05 (0.04, 0.06) | |
| order | 2 (1, 4) | 2 (1, 4) | 1 (1, 1) | 1 (1, 1) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | Hormone_therapies | count | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 |
| time | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | ||
| n | 7 (6, 9) | 0 (0, 2) | 4 (2, 5) | 2 (1, 4) | 0 (0, 1) | 1 (1, 2) | 0 (0, 1) | 0 (0, 2) | 0 (0, 2) | 2 (0, 2) | 1 (1, 2) | 2 (0, 3) | 0 (0, 2) | 1 (0, 2) | 2 (1, 2) | 0 (0, 2) | ||
| post_p | 0.67 (0.56, 0.76) | 0.88 (0.88, 0.88) | 0.69 (0.63, 0.79) | 0.58 (0.56, 0.62) | 0.59 (0.57, 0.61) | 0.61 (0.55, 0.66) | 0.52 (0.52, 0.52) | 0.78 (0.78, 0.78) | 0.66 (0.61, 0.71) | 0.7 (0.67, 0.74) | 0.56 (0.56, 0.56) | 0.57 (0.57, 0.57) | NA (NA, NA) | 0.56 (0.56, 0.56) | 0.56 (0.53, 0.59) | 0.67 (0.67, 0.67) | ||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.054 (0.015, 0.1) | 0.09 (0.09, 0.09) | 0 (0, 0.05) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0.303) | 0.191 (0.191, 0.191) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1.006) | 0 (0, 0.245) | 0.227 (0.045, 0.408) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| Taxel_therapies | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | |
| time | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | ||
| n | 10 (5, 15) | 2 (0, 4) | 5 (4, 6) | 3 (3, 3) | 2 (1, 2) | 0 (0, 0) | 0 (0, 0) | 2 (0, 4) | 2 (1, 2) | 2 (1, 2) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 1 (0, 2) | 1 (0, 2) | ||
| post_p | 0.64 (0.56, 0.73) | 0.66 (0.66, 0.66) | 0.67 (0.6, 0.74) | 0.52 (0.52, 0.53) | 0.65 (0.58, 0.72) | NA (NA, NA) | NA (NA, NA) | 0.64 (0.64, 0.64) | 0.56 (0.54, 0.57) | 0.6 (0.55, 0.66) | 0.57 (0.57, 0.57) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.58 (0.58, 0.58) | ||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.013 (0.003, 0.024) | 0.116 (0.116, 0.116) | 0 (0, 0) | 0.055 (0.011, 0.1) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | ||
| Carboplatin | count | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | |
| time | 15 (6, 28) | 15 (6, 28) | 15 (6, 28) | 15 (6, 28) | 15 (6, 28) | 15 (6, 28) | 15 (6, 28) | 15 (6, 28) | 15 (6, 28) | 15 (6, 28) | 15 (6, 28) | 15 (6, 28) | 15 (6, 28) | 15 (6, 28) | 15 (6, 28) | 15 (6, 28) | ||
| n | 14 (8, 40) | 5 (1, 10) | 13 (6, 29) | 6 (2, 24) | 3 (1, 8) | 3 (1, 9) | 3 (0, 7) | 3 (0, 7) | 5 (1, 12) | 3 (1, 8) | 4 (0, 7) | 3 (0, 8) | 2 (0, 6) | 2 (0, 6) | 3 (0, 6) | 3 (1, 6) | ||
| post_p | 0.68 (0.52, 0.9) | 0.64 (0.53, 0.77) | 0.63 (0.53, 0.77) | 0.57 (0.52, 0.71) | 0.61 (0.51, 0.86) | 0.66 (0.52, 0.86) | 0.65 (0.53, 0.85) | 0.69 (0.53, 0.86) | 0.67 (0.55, 0.96) | 0.56 (0.51, 0.79) | 0.7 (0.56, 0.89) | 0.58 (0.55, 0.74) | 0.62 (0.58, 0.89) | 0.72 (0.56, 0.88) | 0.59 (0.52, 0.84) | 0.75 (0.56, 0.88) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0.085 (0.063, 0.096) | 0.071 (0, 0.106) | 0.1 (0.05, 0.13) | 0.087 (0.008, 0.131) | 0.034 (0, 0.097) | 0.023 (0, 0.052) | 0.015 (0, 0.063) | 0.021 (0, 0.072) | 0.034 (0, 0.109) | 0.087 (0, 0.134) | 0.048 (0, 0.071) | 0.084 (0, 0.129) | 0.011 (0, 0.064) | 0 (0, 0.036) | 0 (0, 0.078) | 0 (0, 0.043) | ||
| Niraparib | count | 19 | 19 | 19 | 19 | 19 | 19 | 19 | 19 | 19 | 19 | 19 | 19 | 19 | 19 | 19 | 19 | |
| time | 22 (5, 34) | 22 (5, 34) | 22 (5, 34) | 22 (5, 34) | 22 (5, 34) | 22 (5, 34) | 22 (5, 34) | 22 (5, 34) | 22 (5, 34) | 22 (5, 34) | 22 (5, 34) | 22 (5, 34) | 22 (5, 34) | 22 (5, 34) | 22 (5, 34) | 22 (5, 34) | ||
| n | 21 (6, 51) | 4 (1, 15) | 18 (4, 31) | 9 (3, 21) | 5 (2, 8) | 3 (1, 10) | 3 (1, 7) | 2 (0, 7) | 6 (1, 12) | 6 (1, 10) | 5 (1, 12) | 4 (1, 11) | 3 (1, 6) | 4 (2, 7) | 3 (0, 6) | 3 (1, 8) | ||
| post_p | 0.68 (0.61, 0.82) | 0.63 (0.51, 0.77) | 0.66 (0.53, 0.87) | 0.62 (0.53, 0.82) | 0.73 (0.64, 0.94) | 0.82 (0.59, 0.94) | 0.73 (0.57, 0.9) | 0.75 (0.65, 0.93) | 0.6 (0.51, 0.74) | 0.59 (0.51, 0.8) | 0.7 (0.54, 0.83) | 0.63 (0.52, 0.9) | 0.64 (0.51, 0.93) | 0.76 (0.59, 0.9) | 0.58 (0.52, 0.94) | 0.72 (0.59, 0.86) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0.1 (0.053, 0.112) | 0.071 (0, 0.105) | 0.088 (0.033, 0.11) | 0.091 (0.043, 0.118) | 0.029 (0, 0.068) | 0.036 (0, 0.081) | 0.039 (0, 0.079) | 0.017 (0, 0.037) | 0.089 (0, 0.112) | 0.091 (0.023, 0.122) | 0.066 (0, 0.13) | 0.043 (0, 0.114) | 0.023 (0, 0.078) | 0.017 (0, 0.051) | 0.036 (0, 0.103) | 0.018 (0, 0.051) | ||
| TP53- & AR- | Hormone_therapies | count | 9 | 9 | 9 | 9 | ||||||||||||
| time | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | ||||||||||||||
| n | 18 (16, 25) | 4 (3, 5) | 4 (2, 5) | 4 (2, 10) | ||||||||||||||
| post_p | 0.82 (0.8, 0.9) | 0.6 (0.51, 0.77) | 0.67 (0.53, 0.71) | 0.63 (0.54, 0.84) | ||||||||||||||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.079 (0.051, 0.098) | 0.058 (0, 0.108) | 0.042 (0, 0.114) | 0.029 (0, 0.062) | ||||||||||||||
| Taxel_therapies | count | 11 | 11 | 11 | 11 | |||||||||||||
| time | 12 (10, 19) | 12 (10, 19) | 12 (10, 19) | 12 (10, 19) | ||||||||||||||
| n | 19 (14, 30) | 3 (2, 6) | 3 (2, 5) | 4 (3, 5) | ||||||||||||||
| post_p | 0.8 (0.74, 0.9) | 0.69 (0.51, 0.84) | 0.64 (0.53, 0.76) | 0.68 (0.56, 0.77) | ||||||||||||||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.087 (0.067, 0.098) | 0.048 (0, 0.173) | 0 (0, 0.076) | 0.053 (0, 0.119) | ||||||||||||||
| Carboplatin | count | 134 | 134 | 134 | 134 | |||||||||||||
| time | 18 (9, 29) | 18 (9, 29) | 18 (9, 29) | 18 (9, 29) | ||||||||||||||
| n | 31 (17, 56) | 5 (2, 12) | 5 (2, 13) | 5 (2, 13) | ||||||||||||||
| post_p | 0.77 (0.71, 0.92) | 0.71 (0.53, 0.87) | 0.78 (0.58, 0.94) | 0.78 (0.58, 0.96) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.088 (0.061, 0.115) | 0.07 (0, 0.118) | 0.031 (0, 0.057) | 0.031 (0, 0.061) | ||||||||||||||
| Niraparib | count | 151 | 151 | 151 | 151 | |||||||||||||
| time | 15 (9, 30) | 15 (9, 30) | 15 (9, 30) | 15 (9, 30) | ||||||||||||||
| n | 27 (16, 55) | 4 (1, 12) | 5 (2, 12) | 5 (2, 10) | ||||||||||||||
| post_p | 0.76 (0.71, 0.9) | 0.7 (0.53, 0.84) | 0.8 (0.58, 0.95) | 0.78 (0.6, 0.95) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.088 (0.054, 0.11) | 0.073 (0, 0.104) | 0.025 (0, 0.056) | 0.025 (0, 0.059) | ||||||||||||||
| TP53+ | Hormone_therapies | count | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | ||||||||
| time | 8 (7, 9) | 8 (7, 9) | 8 (7, 9) | 8 (7, 9) | 8 (7, 9) | 8 (7, 9) | 8 (7, 9) | 8 (7, 9) | ||||||||||
| n | 12 (9, 12) | 6 (3, 8) | 2 (0, 3) | 1 (0, 2) | 4 (3, 5) | 2 (0, 2) | 2 (1, 3) | 0 (0, 2) | ||||||||||
| post_p | 0.82 (0.77, 0.88) | 0.72 (0.64, 0.86) | 0.53 (0.51, 0.55) | 0.65 (0.62, 0.68) | 0.7 (0.67, 0.83) | 0.54 (0.54, 0.6) | 0.52 (0.51, 0.59) | NA (NA, NA) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.042 (0.029, 0.071) | 0.022 (0, 0.091) | 0 (0, 0) | 0 (0, 0) | 0.061 (0, 0.155) | 0.064 (0, 0.144) | 0.08 (0, 0.225) | 0 (0, 0.506) | ||||||||||
| Taxel_therapies | count | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | |||||||||
| time | 10 (9, 11) | 10 (9, 11) | 10 (9, 11) | 10 (9, 11) | 10 (9, 11) | 10 (9, 11) | 10 (9, 11) | 10 (9, 11) | ||||||||||
| n | 10 (9, 15) | 7 (6, 9) | 1 (0, 3) | 2 (1, 4) | 3 (1, 4) | 1 (0, 3) | 1 (1, 3) | 3 (0, 4) | ||||||||||
| post_p | 0.79 (0.74, 0.85) | 0.72 (0.68, 0.76) | 0.53 (0.52, 0.86) | 0.55 (0.52, 0.71) | 0.77 (0.67, 0.82) | 0.84 (0.62, 0.88) | 0.58 (0.53, 0.61) | 0.55 (0.53, 0.7) | ||||||||||
| r_prob | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.047 (0.034, 0.053) | 0.055 (0.05, 0.085) | 0.028 (0.006, 0.127) | 0.061 (0, 0.131) | 0 (0, 0.042) | 0 (0, 0) | 0 (0, 0.05) | 0.068 (0.051, 0.115) | ||||||||||
| Carboplatin | count | 25 | 25 | 25 | 25 | 25 | 25 | 25 | 25 | |||||||||
| time | 18 (9, 27) | 18 (9, 27) | 18 (9, 27) | 18 (9, 27) | 18 (9, 27) | 18 (9, 27) | 18 (9, 27) | 18 (9, 27) | ||||||||||
| n | 14 (7, 29) | 10 (4, 18) | 3 (1, 7) | 3 (0, 8) | 4 (0, 7) | 4 (1, 8) | 3 (0, 6) | 2 (1, 5) | ||||||||||
| post_p | 0.76 (0.73, 0.88) | 0.75 (0.6, 0.85) | 0.73 (0.56, 0.92) | 0.76 (0.59, 0.93) | 0.64 (0.51, 0.77) | 0.74 (0.54, 0.86) | 0.68 (0.52, 0.91) | 0.66 (0.54, 0.9) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.077 (0.033, 0.111) | 0.074 (0.014, 0.099) | 0.018 (0, 0.072) | 0.025 (0, 0.046) | 0.077 (0, 0.145) | 0.06 (0, 0.107) | 0.009 (0, 0.061) | 0 (0, 0.091) | ||||||||||
| Niraparib | count | 27 | 27 | 27 | 27 | 27 | 27 | 27 | 27 | |||||||||
| time | 16 (10, 29) | 16 (10, 29) | 16 (10, 29) | 16 (10, 29) | 16 (10, 29) | 16 (10, 29) | 16 (10, 29) | 16 (10, 29) | ||||||||||
| n | 19 (8, 32) | 11 (5, 21) | 3 (1, 7) | 3 (1, 6) | 5 (1, 9) | 4 (2, 7) | 3 (1, 4) | 2 (1, 5) | ||||||||||
| post_p | 0.78 (0.71, 0.88) | 0.78 (0.71, 0.87) | 0.77 (0.62, 0.94) | 0.69 (0.54, 0.84) | 0.71 (0.56, 0.87) | 0.69 (0.53, 0.83) | 0.63 (0.52, 0.81) | 0.67 (0.52, 0.91) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.073 (0.032, 0.104) | 0.079 (0.036, 0.097) | 0.016 (0, 0.048) | 0 (0, 0.048) | 0.059 (0, 0.105) | 0.07 (0, 0.116) | 0.016 (0, 0.085) | 0 (0, 0.057) | ||||||||||
| DRD+ | Carboplatin | count | 322 | 322 | 322 | 322 | 322 | 322 | 322 | 322 | ||||||||
| time | 22 (14, 33) | 22 (14, 33) | 22 (14, 33) | 22 (14, 33) | 22 (14, 33) | 22 (14, 33) | 22 (14, 33) | 22 (14, 33) | ||||||||||
| n | 7 (3, 15) | 7 (3, 15) | 4 (1, 9) | 4 (2, 10) | 4 (1, 9) | 4 (2, 9) | 4 (2, 9) | 4 (2, 9) | ||||||||||
| post_p | 0.82 (0.65, 0.98) | 0.83 (0.63, 0.97) | 0.74 (0.54, 0.93) | 0.75 (0.55, 0.92) | 0.75 (0.54, 0.93) | 0.76 (0.55, 0.92) | 0.74 (0.56, 0.92) | 0.75 (0.54, 0.93) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.032 (0, 0.059) | 0.031 (0, 0.061) | 0.03 (0, 0.08) | 0.032 (0, 0.069) | 0.029 (0, 0.066) | 0.028 (0, 0.073) | 0.031 (0, 0.067) | 0.03 (0, 0.084) | ||||||||||
| Niraparib | count | 321 | 321 | 321 | 321 | 321 | 321 | 321 | 321 | |||||||||
| time | 21 (13, 34) | 21 (13, 34) | 21 (13, 34) | 21 (13, 34) | 21 (13, 34) | 21 (13, 34) | 21 (13, 34) | 21 (13, 34) | ||||||||||
| n | 7 (3, 15) | 6 (3, 14) | 4 (1, 9) | 4 (1, 9) | 4 (2, 8) | 4 (2, 8) | 4 (1, 9) | 4 (1, 9) | ||||||||||
| post_p | 0.82 (0.61, 0.99) | 0.85 (0.64, 0.97) | 0.75 (0.57, 0.93) | 0.76 (0.54, 0.93) | 0.74 (0.54, 0.94) | 0.74 (0.53, 0.92) | 0.74 (0.54, 0.93) | 0.75 (0.54, 0.93) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.03 (0, 0.062) | 0.031 (0, 0.063) | 0.029 (0, 0.069) | 0.027 (0, 0.06) | 0.028 (0, 0.073) | 0.027 (0, 0.068) | 0.026 (0, 0.076) | 0.029 (0, 0.066) | ||||||||||
| TEfus+ | Hormone_therapies | count | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | ||||||||
| time | 13 (9, 16) | 13 (9, 16) | 13 (9, 16) | 13 (9, 16) | 13 (9, 16) | 13 (9, 16) | 13 (9, 16) | 13 (9, 16) | ||||||||||
| n | 5 (3, 7) | 7 (4, 15) | 4 (3, 5) | 2 (1, 3) | 3 (2, 4) | 2 (1, 4) | 2 (0, 5) | 4 (3, 4) | ||||||||||
| post_p | 0.81 (0.7, 0.86) | 0.68 (0.62, 0.81) | 0.58 (0.54, 0.65) | 0.52 (0.51, 0.56) | 0.68 (0.54, 0.87) | 0.62 (0.57, 0.67) | 0.64 (0.54, 0.73) | 0.66 (0.55, 0.74) | ||||||||||
| r_prob | 0.35 (0.35, 0.35) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.019 (0, 0.059) | 0.048 (0.014, 0.083) | 0.038 (0.008, 0.085) | 0.075 (0.021, 0.101) | 0.088 (0.061, 0.137) | 0 (0, 0.069) | 0.028 (0.006, 0.041) | 0.045 (0.011, 0.073) | ||||||||||
| Taxel_therapies | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | |||||||||
| time | 12 (12, 13) | 12 (12, 13) | 12 (12, 13) | 12 (12, 13) | 12 (12, 13) | 12 (12, 13) | 12 (12, 13) | 12 (12, 13) | ||||||||||
| n | 6 (5, 6) | 10 (9, 12) | 2 (1, 4) | 1 (1, 1) | 4 (3, 4) | 2 (0, 3) | 2 (1, 2) | 0 (0, 1) | ||||||||||
| post_p | 0.63 (0.53, 0.73) | 0.87 (0.86, 0.87) | 0.83 (0.83, 0.83) | 0.66 (0.65, 0.68) | 0.7 (0.7, 0.71) | 0.62 (0.62, 0.62) | 0.62 (0.61, 0.63) | 0.55 (0.55, 0.55) | ||||||||||
| r_prob | 0.29 (0.29, 0.29) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.06 (0.032, 0.087) | 0.061 (0.058, 0.064) | 0.119 (0.119, 0.119) | 0 (0, 0) | 0.103 (0.061, 0.145) | 0.052 (0.052, 0.052) | 0.04 (0.008, 0.073) | 0 (0, 0) | ||||||||||
| Carboplatin | count | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | |||||||||
| time | 14 (10, 28) | 14 (10, 28) | 14 (10, 28) | 14 (10, 28) | 14 (10, 28) | 14 (10, 28) | 14 (10, 28) | 14 (10, 28) | ||||||||||
| n | 4 (2, 11) | 11 (6, 17) | 3 (1, 7) | 2 (0, 5) | 4 (3, 7) | 2 (1, 6) | 3 (1, 4) | 3 (1, 7) | ||||||||||
| post_p | 0.64 (0.52, 0.79) | 0.79 (0.72, 0.94) | 0.7 (0.55, 0.91) | 0.61 (0.53, 0.77) | 0.65 (0.54, 0.78) | 0.63 (0.52, 0.8) | 0.66 (0.53, 0.85) | 0.71 (0.58, 0.82) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.072 (0.007, 0.134) | 0.068 (0.034, 0.097) | 0.006 (0, 0.054) | 0 (0, 0.056) | 0.07 (0.012, 0.127) | 0.048 (0, 0.125) | 0.018 (0, 0.077) | 0 (0, 0.091) | ||||||||||
| Niraparib | count | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | |||||||||
| time | 15 (10, 24) | 15 (10, 24) | 15 (10, 24) | 15 (10, 24) | 15 (10, 24) | 15 (10, 24) | 15 (10, 24) | 15 (10, 24) | ||||||||||
| n | 4 (1, 6) | 8 (4, 17) | 5 (1, 9) | 3 (1, 5) | 3 (2, 7) | 4 (2, 7) | 3 (2, 6) | 2 (1, 5) | ||||||||||
| post_p | 0.67 (0.54, 0.83) | 0.76 (0.7, 0.89) | 0.82 (0.63, 0.92) | 0.68 (0.53, 0.86) | 0.7 (0.56, 0.81) | 0.7 (0.54, 0.78) | 0.72 (0.53, 0.84) | 0.65 (0.54, 0.83) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.055 (0, 0.089) | 0.064 (0.035, 0.091) | 0 (0, 0.039) | 0 (0, 0.075) | 0.077 (0, 0.11) | 0.07 (0, 0.124) | 0.017 (0, 0.069) | 0.034 (0, 0.072) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | Hormone_therapies | count | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 |
| time | 13 (6, 25) | 13 (6, 25) | 13 (6, 25) | 13 (6, 25) | 13 (6, 25) | 13 (6, 25) | 13 (6, 25) | 13 (6, 25) | 13 (6, 25) | 13 (6, 25) | 13 (6, 25) | 13 (6, 25) | 13 (6, 25) | 13 (6, 25) | 13 (6, 25) | 13 (6, 25) | ||
| n | 19 (12, 28) | 4 (2, 6) | 8 (4, 26) | 5 (4, 13) | 3 (2, 6) | 2 (0, 8) | 1 (0, 4) | 2 (0, 7) | 3 (2, 6) | 4 (0, 6) | 4 (1, 9) | 2 (0, 8) | 2 (0, 7) | 2 (0, 5) | 2 (0, 6) | 3 (0, 4) | ||
| post_p | 0.33 (0.05, 0.44) | 0.39 (0.31, 0.45) | 0.38 (0.24, 0.46) | 0.41 (0.31, 0.49) | 0.41 (0.27, 0.44) | 0.39 (0.16, 0.41) | 0.42 (0.19, 0.47) | 0.39 (0.32, 0.45) | 0.41 (0.29, 0.48) | 0.38 (0.27, 0.42) | 0.36 (0.1, 0.45) | 0.4 (0.34, 0.46) | 0.31 (0.23, 0.43) | 0.37 (0.24, 0.44) | 0.29 (0.24, 0.43) | 0.3 (0.24, 0.37) | ||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.124 (0.096, 0.181) | 0.137 (0.085, 0.167) | 0.149 (0.115, 0.295) | 0.128 (0.071, 0.207) | 0.118 (0.086, 0.131) | 0.164 (0.1, 0.511) | 0.129 (0.033, 0.242) | 0.112 (0.067, 0.846) | 0.18 (0.118, 0.389) | 0.142 (0.037, 0.299) | 0.168 (0.114, 0.411) | 0.134 (0.107, 0.331) | 0.163 (0.092, 0.888) | 0.146 (0.117, 0.212) | 0.204 (0.105, 0.245) | 0.118 (0.11, 0.151) | ||
| Taxel_therapies | count | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | |
| time | 14 (4, 28) | 14 (4, 28) | 14 (4, 28) | 14 (4, 28) | 14 (4, 28) | 14 (4, 28) | 14 (4, 28) | 14 (4, 28) | 14 (4, 28) | 14 (4, 28) | 14 (4, 28) | 14 (4, 28) | 14 (4, 28) | 14 (4, 28) | 14 (4, 28) | 14 (4, 28) | ||
| n | 22 (6, 54) | 6 (3, 10) | 12 (5, 22) | 8 (3, 14) | 4 (2, 7) | 2 (0, 6) | 1 (0, 1) | 2 (1, 4) | 4 (1, 7) | 2 (0, 4) | 2 (0, 5) | 2 (0, 3) | 4 (1, 6) | 2 (2, 3) | 4 (1, 8) | 1 (0, 5) | ||
| post_p | 0.35 (0.16, 0.46) | 0.36 (0.32, 0.44) | 0.37 (0.26, 0.47) | 0.33 (0.2, 0.46) | 0.28 (0.22, 0.39) | 0.35 (0.33, 0.36) | 0.41 (0.3, 0.48) | 0.34 (0.17, 0.42) | 0.24 (0.21, 0.41) | 0.27 (0.14, 0.38) | 0.28 (0.25, 0.39) | 0.32 (0.26, 0.36) | 0.42 (0.17, 0.45) | 0.25 (0.14, 0.4) | 0.37 (0.22, 0.43) | 0.24 (0.16, 0.32) | ||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.14 (0.106, 0.2) | 0.133 (0.097, 0.185) | 0.18 (0.128, 0.262) | 0.128 (0.112, 0.151) | 0.143 (0.113, 0.32) | 0.173 (0.123, 3.05) | 0.174 (0.035, 1.541) | 0.224 (0.027, 0.437) | 0.306 (0.262, 0.433) | 0.628 (0.361, 1.226) | 0.184 (0.136, 0.58) | 0.225 (0.162, 0.746) | 0.263 (0.138, 0.841) | 0.297 (0.02, 0.554) | 0.136 (0.118, 0.202) | 0.183 (0.165, 0.202) | ||
| Carboplatin | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| time | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | ||
| n | 6 (6, 6) | 1 (1, 1) | 6 (6, 6) | 3 (3, 3) | 0 (0, 0) | 1 (1, 1) | 0 (0, 0) | 2 (2, 2) | 3 (3, 3) | 0 (0, 0) | 0 (0, 0) | 1 (1, 1) | 0 (0, 0) | 4 (4, 4) | 1 (1, 1) | 2 (2, 2) | ||
| post_p | 0.05 (0.05, 0.05) | 0.48 (0.48, 0.48) | 0.19 (0.19, 0.19) | 0.47 (0.47, 0.47) | NA (NA, NA) | 0.22 (0.22, 0.22) | NA (NA, NA) | NA (NA, NA) | 0.48 (0.48, 0.48) | NA (NA, NA) | NA (NA, NA) | 0.5 (0.5, 0.5) | NA (NA, NA) | 0.45 (0.45, 0.45) | NA (NA, NA) | 0.43 (0.43, 0.43) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0.257 (0.257, 0.257) | 0 (0, 0) | 0.211 (0.211, 0.211) | 0.141 (0.141, 0.141) | NA (NA, NA) | 0.955 (0.955, 0.955) | NA (NA, NA) | 0 (0, 0) | 0.141 (0.141, 0.141) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| TP53- & AR- | Hormone_therapies | count | 203 | 203 | 203 | 203 | ||||||||||||
| time | 17 (10, 30) | 17 (10, 30) | 17 (10, 30) | 17 (10, 30) | ||||||||||||||
| n | 26 (15, 56) | 6 (2, 11) | 6 (3, 12) | 5 (2, 11) | ||||||||||||||
| post_p | 0.3 (0.11, 0.46) | 0.39 (0.15, 0.48) | 0.34 (0.09, 0.48) | 0.31 (0.12, 0.47) | ||||||||||||||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.128 (0.102, 0.172) | 0.145 (0.096, 0.325) | 0.128 (0.079, 0.266) | 0.14 (0.085, 0.305) | ||||||||||||||
| Taxel_therapies | count | 216 | 216 | 216 | 216 | |||||||||||||
| time | 17 (10, 31) | 17 (10, 31) | 17 (10, 31) | 17 (10, 31) | ||||||||||||||
| n | 28 (16, 56) | 6 (2, 13) | 5 (2, 12) | 6 (3, 13) | ||||||||||||||
| post_p | 0.32 (0.09, 0.47) | 0.36 (0.12, 0.48) | 0.33 (0.11, 0.47) | 0.31 (0.1, 0.47) | ||||||||||||||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.127 (0.104, 0.179) | 0.152 (0.095, 0.336) | 0.133 (0.079, 0.327) | 0.13 (0.081, 0.338) | ||||||||||||||
| Carboplatin | count | 9 | 9 | 9 | 9 | |||||||||||||
| time | 10 (9, 14) | 10 (9, 14) | 10 (9, 14) | 10 (9, 14) | ||||||||||||||
| n | 17 (14, 23) | 4 (2, 7) | 4 (3, 5) | 4 (0, 6) | ||||||||||||||
| post_p | 0.22 (0.13, 0.35) | 0.35 (0.21, 0.44) | 0.43 (0.26, 0.47) | 0.44 (0.23, 0.48) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.141 (0.12, 0.183) | 0.137 (0.081, 0.524) | 0.102 (0.053, 0.146) | 0.11 (0.054, 0.204) | ||||||||||||||
| Niraparib | count | 6 | 6 | 6 | 6 | |||||||||||||
| time | 11 (10, 18) | 11 (10, 18) | 11 (10, 18) | 11 (10, 18) | ||||||||||||||
| n | 20 (18, 26) | 3 (1, 8) | 3 (1, 5) | 4 (1, 7) | ||||||||||||||
| post_p | 0.34 (0.12, 0.48) | 0.3 (0.17, 0.42) | 0.41 (0.33, 0.47) | 0.45 (0.34, 0.47) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.118 (0.095, 0.162) | 0.302 (0.097, 0.358) | 0.112 (0.101, 0.801) | 0.122 (0.035, 0.172) | ||||||||||||||
| TP53+ | Hormone_therapies | count | 75 | 75 | 75 | 75 | 75 | 75 | 75 | 75 | ||||||||
| time | 18 (9, 30) | 18 (9, 30) | 18 (9, 30) | 18 (9, 30) | 18 (9, 30) | 18 (9, 30) | 18 (9, 30) | 18 (9, 30) | ||||||||||
| n | 15 (9, 32) | 10 (4, 24) | 4 (0, 8) | 3 (1, 8) | 5 (1, 11) | 4 (1, 8) | 4 (1, 8) | 3 (1, 9) | ||||||||||
| post_p | 0.33 (0.11, 0.48) | 0.35 (0.17, 0.49) | 0.33 (0.14, 0.46) | 0.33 (0.15, 0.44) | 0.35 (0.16, 0.48) | 0.36 (0.15, 0.49) | 0.33 (0.18, 0.48) | 0.35 (0.12, 0.46) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.133 (0.105, 0.198) | 0.135 (0.107, 0.23) | 0.131 (0.079, 0.334) | 0.151 (0.069, 0.417) | 0.156 (0.091, 0.35) | 0.174 (0.102, 0.352) | 0.125 (0.048, 0.316) | 0.14 (0.088, 0.344) | ||||||||||
| Taxel_therapies | count | 49 | 49 | 49 | 49 | 49 | 49 | 49 | 49 | |||||||||
| time | 19 (9, 32) | 19 (9, 32) | 19 (9, 32) | 19 (9, 32) | 19 (9, 32) | 19 (9, 32) | 19 (9, 32) | 19 (9, 32) | ||||||||||
| n | 18 (8, 29) | 13 (5, 22) | 4 (1, 8) | 4 (1, 7) | 4 (1, 10) | 5 (1, 10) | 5 (0, 9) | 4 (1, 9) | ||||||||||
| post_p | 0.29 (0.12, 0.47) | 0.36 (0.15, 0.48) | 0.33 (0.16, 0.45) | 0.35 (0.2, 0.47) | 0.34 (0.18, 0.45) | 0.39 (0.14, 0.48) | 0.34 (0.15, 0.48) | 0.31 (0.18, 0.46) | ||||||||||
| r_prob | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.138 (0.11, 0.181) | 0.14 (0.108, 0.25) | 0.115 (0.063, 0.317) | 0.125 (0.081, 0.379) | 0.161 (0.11, 0.373) | 0.167 (0.088, 0.383) | 0.129 (0.06, 0.339) | 0.151 (0.097, 0.579) | ||||||||||
| Carboplatin | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | |||||||||
| time | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | ||||||||||
| n | 10 (8, 13) | 6 (4, 9) | 2 (1, 2) | 2 (0, 4) | 4 (2, 5) | 3 (1, 5) | 2 (0, 3) | 0 (0, 0) | ||||||||||
| post_p | 0.35 (0.23, 0.47) | 0.33 (0.25, 0.41) | 0.4 (0.32, 0.48) | 0.46 (0.46, 0.46) | 0.39 (0.34, 0.44) | 0.31 (0.24, 0.38) | 0.28 (0.28, 0.28) | NA (NA, NA) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.131 (0.116, 0.146) | 0.156 (0.136, 0.176) | 14.383 (2.877, 25.889) | 0.07 (0.07, 0.07) | 0.132 (0.131, 0.133) | 0.248 (0.14, 0.356) | 0.131 (0.131, 0.131) | NA (NA, NA) | ||||||||||
| Niraparib | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||
| time | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | ||||||||||
| n | 4 (4, 4) | 9 (9, 9) | 2 (2, 2) | 3 (3, 3) | 5 (5, 5) | 3 (3, 3) | 1 (1, 1) | 1 (1, 1) | ||||||||||
| post_p | 0.25 (0.25, 0.25) | 0.28 (0.28, 0.28) | NA (NA, NA) | 0.48 (0.48, 0.48) | 0.34 (0.34, 0.34) | 0.44 (0.44, 0.44) | 0.46 (0.46, 0.46) | 0.41 (0.41, 0.41) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.287 (0.287, 0.287) | 0.176 (0.176, 0.176) | 0 (0, 0) | 0 (0, 0) | 0.106 (0.106, 0.106) | 0.155 (0.155, 0.155) | 0 (0, 0) | 0.257 (0.257, 0.257) | ||||||||||
| DRD+ | Hormone_therapies | count | 173 | 173 | 173 | 173 | 173 | 173 | 173 | 173 | ||||||||
| time | 23 (13, 33) | 23 (13, 33) | 23 (13, 33) | 23 (13, 33) | 23 (13, 33) | 23 (13, 33) | 23 (13, 33) | 23 (13, 33) | ||||||||||
| n | 7 (3, 14) | 7 (3, 13) | 5 (2, 9) | 4 (1, 9) | 5 (2, 9) | 4 (2, 8) | 4 (1, 8) | 5 (1, 9) | ||||||||||
| post_p | 0.28 (0.11, 0.47) | 0.28 (0.09, 0.45) | 0.3 (0.11, 0.47) | 0.31 (0.13, 0.46) | 0.33 (0.13, 0.47) | 0.33 (0.12, 0.45) | 0.33 (0.14, 0.47) | 0.35 (0.14, 0.47) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.131 (0.086, 0.231) | 0.139 (0.089, 0.27) | 0.136 (0.079, 0.307) | 0.144 (0.08, 0.346) | 0.125 (0.074, 0.293) | 0.133 (0.071, 0.289) | 0.127 (0.07, 0.303) | 0.14 (0.085, 0.308) | ||||||||||
| Taxel_therapies | count | 160 | 160 | 160 | 160 | 160 | 160 | 160 | 160 | |||||||||
| time | 23 (15, 34) | 23 (15, 34) | 23 (15, 34) | 23 (15, 34) | 23 (15, 34) | 23 (15, 34) | 23 (15, 34) | 23 (15, 34) | ||||||||||
| n | 6 (2, 14) | 6 (3, 13) | 5 (2, 9) | 4 (2, 9) | 5 (2, 9) | 5 (2, 10) | 5 (2, 9) | 5 (1, 9) | ||||||||||
| post_p | 0.3 (0.11, 0.46) | 0.3 (0.09, 0.46) | 0.34 (0.19, 0.47) | 0.3 (0.14, 0.47) | 0.34 (0.13, 0.47) | 0.32 (0.11, 0.47) | 0.32 (0.11, 0.47) | 0.3 (0.14, 0.47) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.126 (0.079, 0.354) | 0.132 (0.086, 0.252) | 0.124 (0.081, 0.277) | 0.129 (0.077, 0.289) | 0.128 (0.076, 0.341) | 0.137 (0.082, 0.334) | 0.133 (0.076, 0.313) | 0.14 (0.084, 0.366) | ||||||||||
| TEfus+ | Hormone_therapies | count | 64 | 64 | 64 | 64 | 64 | 64 | 64 | 64 | ||||||||
| time | 15 (11, 33) | 15 (11, 33) | 15 (11, 33) | 15 (11, 33) | 15 (11, 33) | 15 (11, 33) | 15 (11, 33) | 15 (11, 33) | ||||||||||
| n | 5 (3, 11) | 10 (6, 23) | 5 (2, 10) | 3 (1, 8) | 4 (2, 8) | 4 (1, 9) | 3 (1, 7) | 3 (1, 7) | ||||||||||
| post_p | 0.39 (0.13, 0.48) | 0.31 (0.13, 0.47) | 0.26 (0.09, 0.44) | 0.34 (0.13, 0.46) | 0.37 (0.17, 0.48) | 0.3 (0.09, 0.46) | 0.34 (0.19, 0.46) | 0.33 (0.19, 0.46) | ||||||||||
| r_prob | 0.35 (0.35, 0.35) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.145 (0.094, 0.267) | 0.146 (0.099, 0.241) | 0.157 (0.089, 0.296) | 0.154 (0.062, 0.589) | 0.165 (0.101, 0.466) | 0.177 (0.103, 0.417) | 0.146 (0.061, 0.38) | 0.145 (0.082, 0.335) | ||||||||||
| Taxel_therapies | count | 45 | 45 | 45 | 45 | 45 | 45 | 45 | 45 | |||||||||
| time | 20 (12, 30) | 20 (12, 30) | 20 (12, 30) | 20 (12, 30) | 20 (12, 30) | 20 (12, 30) | 20 (12, 30) | 20 (12, 30) | ||||||||||
| n | 7 (2, 12) | 12 (6, 22) | 5 (2, 14) | 4 (0, 7) | 5 (2, 12) | 5 (2, 9) | 4 (2, 8) | 4 (2, 8) | ||||||||||
| post_p | 0.4 (0.18, 0.48) | 0.37 (0.19, 0.48) | 0.31 (0.13, 0.42) | 0.35 (0.24, 0.45) | 0.32 (0.14, 0.47) | 0.38 (0.18, 0.49) | 0.32 (0.2, 0.45) | 0.34 (0.14, 0.47) | ||||||||||
| r_prob | 0.29 (0.29, 0.29) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.139 (0.09, 0.283) | 0.131 (0.107, 0.185) | 0.127 (0.077, 0.364) | 0.13 (0.081, 0.367) | 0.164 (0.104, 0.431) | 0.182 (0.106, 0.264) | 0.136 (0.083, 0.386) | 0.141 (0.097, 0.313) | ||||||||||
| Carboplatin | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||
| time | 18 (18, 18) | 18 (18, 18) | 18 (18, 18) | 18 (18, 18) | 18 (18, 18) | 18 (18, 18) | 18 (18, 18) | 18 (18, 18) | ||||||||||
| n | 11 (11, 11) | 14 (14, 14) | 12 (12, 12) | 2 (2, 2) | 2 (2, 2) | 2 (2, 2) | 3 (3, 3) | 1 (1, 1) | ||||||||||
| post_p | 0.24 (0.24, 0.24) | 0.19 (0.19, 0.19) | 0.4 (0.4, 0.4) | 0.5 (0.5, 0.5) | 0.43 (0.43, 0.43) | 0.16 (0.16, 0.16) | 0.4 (0.4, 0.4) | 0.35 (0.35, 0.35) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.14 (0.14, 0.14) | 0.143 (0.143, 0.143) | 0.06 (0.06, 0.06) | 0.074 (0.074, 0.074) | 0.147 (0.147, 0.147) | 0.282 (0.282, 0.282) | 0.073 (0.073, 0.073) | 0.807 (0.807, 0.807) | ||||||||||
| Niraparib | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | |||||||||
| time | 9 (8, 10) | 9 (8, 10) | 9 (8, 10) | 9 (8, 10) | 9 (8, 10) | 9 (8, 10) | 9 (8, 10) | 9 (8, 10) | ||||||||||
| n | 3 (3, 3) | 10 (8, 12) | 3 (2, 4) | 0 (0, 0) | 4 (2, 5) | 2 (1, 3) | 3 (2, 4) | 1 (0, 2) | ||||||||||
| post_p | 0.4 (0.34, 0.46) | 0.29 (0.23, 0.34) | 0.35 (0.26, 0.45) | NA (NA, NA) | 0.28 (0.23, 0.33) | 0.41 (0.36, 0.46) | 0.25 (0.1, 0.4) | 0.47 (0.47, 0.47) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.125 (0.084, 0.166) | 0.123 (0.101, 0.146) | 0.123 (0.076, 0.17) | NA (NA, NA) | 0.344 (0.286, 0.401) | 1.454 (0.364, 2.543) | 0.267 (0.224, 0.31) | 0 (0, 0) |